Individual Information
narayana komaravelli
Research Scientist
university of texas medical branch
Educational Qualification
From 1995 to 1998, B.Sc. Microbiology, Genetics and Chemistry , India
From 1998 to 2001, M.S. Medical Laboratory Technology , India
From 2002 to 2006, Ph.D. Biotechnology , India
From 2006 to 2008, postdoctoral fellow in Eucaryotic gene expression lab , India
Research Interests
molecular biology (cloning, recombinant protein expression, purification, refolding)
proteomics (protein structure, protein-protein interactions, DNA-protein interactions)
virology (virus culture, purification, quantification, virus induced pathogenesis, oxidative stress, role of dietary supplements, environmental factors)
vaccine(viral vaccine candidates, bacterial vaccine candidatges, animal studies)
Work Experience
From 2002 to 2006, Research Fellow , JNTU, Hyderabad, India
From 2006 to 2008, Postdoctoral fellow , National Institute of Immunology (NII), New Delhi, India.
From 2008 to 2009, Research Scientist , Orchid Chemicals & Pharmaceuticals, Chennai, India
From 2009 to 2010, Postdoctoral fellow , Internal medicine; University of Texas Medical Branch, Texas, USA
From 2011 to 2013, Postdoctoral fellow , Pediatrics, University of Texas Medical Branch, Texas, USA
From 2013 to present, Research Scientist I , Pediatrics, University of Texas Medical Branch, Texas, USA
Projects
From 2002 to 2006, Vaccine developement
Developed vaccine against Staphylococcus aureus and Staphylococcus epidermidis infections
From 2006 to 2008, Neuronal regulation
Discovered cyclin D1 and CDK5 together modulate aberrantly MAPK pathway and lead to neuronal death due to cell cycle failure
From 2008 to 2009, Protein expression, purification, refolding
Discovered a novel way to refold Penicllin g amidase that was overexpressed in E. coli
From 2011 to 2013, oxidative stress
Worked on RSV induced oxidative stress and Nrf2 signal transduction mechanism in lung cells and discovered
From 2013 to present, Respiratory viruses pathogenesis
Role of the novel gaseous mediator H2S in inflammation; - Beneficiary role of dietary antioxidants in human metapneumovirus infection
Selected Publications
From 1995 to 1998, B.Sc. Microbiology, Genetics and Chemistry , India
From 1998 to 2001, M.S. Medical Laboratory Technology , India
From 2002 to 2006, Ph.D. Biotechnology , India
From 2006 to 2008, postdoctoral fellow in Eucaryotic gene expression lab , India
Research Interests
molecular biology (cloning, recombinant protein expression, purification, refolding)
proteomics (protein structure, protein-protein interactions, DNA-protein interactions)
virology (virus culture, purification, quantification, virus induced pathogenesis, oxidative stress, role of dietary supplements, environmental factors)
vaccine(viral vaccine candidates, bacterial vaccine candidatges, animal studies)
Work Experience
From 2002 to 2006, Research Fellow , JNTU, Hyderabad, India
From 2006 to 2008, Postdoctoral fellow , National Institute of Immunology (NII), New Delhi, India.
From 2008 to 2009, Research Scientist , Orchid Chemicals & Pharmaceuticals, Chennai, India
From 2009 to 2010, Postdoctoral fellow , Internal medicine; University of Texas Medical Branch, Texas, USA
From 2011 to 2013, Postdoctoral fellow , Pediatrics, University of Texas Medical Branch, Texas, USA
From 2013 to present, Research Scientist I , Pediatrics, University of Texas Medical Branch, Texas, USA
Projects
From 2002 to 2006, Vaccine developement
Developed vaccine against Staphylococcus aureus and Staphylococcus epidermidis infections
From 2006 to 2008, Neuronal regulation
Discovered cyclin D1 and CDK5 together modulate aberrantly MAPK pathway and lead to neuronal death due to cell cycle failure
From 2008 to 2009, Protein expression, purification, refolding
Discovered a novel way to refold Penicllin g amidase that was overexpressed in E. coli
From 2011 to 2013, oxidative stress
Worked on RSV induced oxidative stress and Nrf2 signal transduction mechanism in lung cells and discovered
From 2013 to present, Respiratory viruses pathogenesis
Role of the novel gaseous mediator H2S in inflammation; - Beneficiary role of dietary antioxidants in human metapneumovirus infection
Selected Publications
Journal Articles
Conference Papers
| 1. |
Narayana Komaravelli*, Kelley JP, Garofalo MP, Wu H, Casola A, and Kolli D. Role of dietary antioxidants in human metapneumovirus infection. Virus Research (Accepted) (*Corresponding Author) |
| 2. |
Narayana Komaravelli, Antonella Casola. Respiratory viral infections and subversion of cellular anti-oxidant defenses. Journal of Pharmacogenomics & Pharmacoproteomics. 2014 Sep 30;5:4 |
| 3. |
Yashoda M. Hosakote , Narayana Komaravelli , Nicolas Mautemps , Tianshuang Liu , Roberto P. Garofalo, Antonella Casola. Antioxidant mimetics modulate oxidative stress and cellular signaling in airway epithelial cells infected with Respiratory Syncytial Virus. Am J Physiol Lung Cell Mol Physiol . 2012 Dec 1;303(11):L991-1000. |
| 4. |
Prashant Kumar Modi*, Narayana Komaravelli*, Neha Singh and Pushkar Sharma. Interplay between MEK-ERK signaling, cyclin D1 and cyclin dependent kinase 5 regulates cell cycle reentry and apoptosis of neurons. Mol Biol Cell. 2012 Sep;23(18):3722-30 (*Joint 1st author) |
| 5. |
Ravi Nagaraj Vellanki, Narayana Komaravelli, Tatianeni Radhika, Lakshmi Narasu Mangamoori. Expression of hepatitis B surface antigen in Saccharomyces cerevisiae utilizing glyceraldeyhyde-3-phosphate dehydrogenase promoter of Pichia pastoris. Biotechnol Lett. 2007 Feb;29(2):313-8. |
| 6. |
Choudhary ML, Jawaid S, Ahuja MK, Narayana K, Gupta P, Bhuyan AK, Khatri GS. Open reading frame yjbI of Bacillus subtilis codes for truncated hemoglobin. Protein Expression and Purification. 2005 Jun; 41(2):363-72. |
| 7. |
Biju Joseph, Narayana Komaravelli, Mamatha G, Raman G, Govindasamy Kumaramanickavel. Mutational scanning of RB1 gene by multiplex PCR. Indian Journal of Biotechnology. 2005 Apr; (4): 194 – 200. |
| 8. |
Kumaramanickavel G, Joseph B, Narayana K, Natesh S, Mamatha G, Shanmugam MP, Elamparathi A, Biswas J. Molecular-genetic analysis of two cases with retinoblastoma: benefits for disease management. J Genet. 2003 Apr-Aug; 82(1-2):39-44. |
| 1. |
Narayana Komaravelli1, Bing Tiang, Teodora Ivanciuc1, Allan R. Brasier, Roberto P. Garofalo, and Antonella Casola Respiratory Syncytial Virus Infection Downregulates Antioxidant Enzyme Expression by Triggering Nrf2 Degradation. At ASBMB Annual meeting 2015 – Boston, MA, USA – Mar 30, 2015 |
| 2. |
Narayana Komaravelli, Tianshuang Liu,Tian Bing, Roberto. P. Garofalo, Antonella Casola. RSV Induces Oxidative Stress by Reducing Antioxidant Enzymes via Nrf2 Deprivation. At At UTMB – IHII/McLaughlin colloquium on Apr 11, 2014. |
| 3. |
Narayana Komaravelli, Tianshuang Liu,Tian Bing, Roberto. P. Garofalo, Antonella Casola. RSV Induces Oxidative Stres by Reducing Antioxidant Enzymes via Nrf2 Deprivation. At ASCB 2013 annual meeting – New Orleans, LA, USA on Dec 16, 2013. |
| 4. |
Narayana Komaravelli, Tianshuang Liu, Roberto. P. Garofalo, Antonella Casola. RSV induces oxidative stress by modulating antioxidant enzymes via Nrf2 degradation. At UTMB – IHII/McLaughlin colloquium on Apr 12, 2013. |
| 5. |
Prashant Modi, Surbhi Jaiswal, Narayan Komaravelli, Neha Singh & Pushkar Sharma. Novel insights into how neuronal cell cycle re-entry may cause apoptosis. At 27th Annual Meeting of Society for Neurochemistry, India (SNCI) & International Conference on recent advances in molecular mechanisms in neurological disorders. February 21-23, 2013 held at AIIMS New Delhi, India. |
| 6. |
Narayana Komaravelli, Roberto. P. Garofalo, Antonella Casola. NF-κB and NRF2 pathways cross talk during Respiratory Syncitial Virus pathogenesis. At RSV 2012 Symposium, SantaFe, New Mexico, USA on Sep27-30, 2012 |
| 7. |
Narayana Komaravelli, Roberto. P. Garofalo, Antonella Casola. NF-κB and NRF2 pathways cross talk during Respiratory Syncitial Virus pathogenesis. At UTMB – IHII/McLaughlin colloquium on Apr 13, 2012. |
| 8. |
Narayana Komaravelli, Yashoda.M. Hosakote, Roberto. P. Garofalo, Antonella Casola. RSV modulates antioxidant responsive element (ARE)-dependent binding of transcriptional factors to ARE sequences in the promoters of Antioxidant Enzymes. Presented at UTMB Post Doc appreciation day Sep 2011 |