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Vol.4 , No. 1, Publication Date: Feb. 5, 2018, Page: 11-14
 remain as an important problem and the exact mechanism has not been elucidated. Many studies have been reported describing the relation between response and Glucocorticoid Receptors α/β (GR α/β) expression in childhood leukemia. In present study aimed to determine expression levels of glucocorticoid receptors and to evaluate the relationship with clinical parameters and development of glucocorticoid resistance in children with acute leukemia. To test this hypothesis, GRα/β messenger-RiboNucleic Acid (m-RNA) expression levels were determined in 13 children wtih acute leukemia patients. This study ‘results reported that GRβ expression levels were high at leukemia. The results in this article seem to be the first screening results of the GRα/β m-RNA expression levels studied by quantitative Real Time Polymerase Chain Reaction (qRT- PCR) in Turkish acute leukemia patients. The cause of GC resistance in childhood leukemia is largely unknown. The clinical glucocorticoid resistance positivity and the GRα/β ratio may be effective in leading leukemia in glucocorticoid resistance.&picture=http://www.aascit.org/aascit/decorators/img/journal/980.jpg)
| [1] | Dilara Fatma Akin Bali, Niğde Ömer Halisdemir University, Faculty of Medicine, Medical Biology, Niğde, Turkey. |
| [2] | Mine Mumcuoglu, LÖSANTE Children’s and Adult Hospital, Ankara, Turkey. |
| [3] | Deniz Aslar Oner, LÖSANTE Children’s and Adult Hospital, Ankara, Turkey. |
| [4] | Ahmet Emin Kurekci, LÖSANTE Children’s and Adult Hospital, Ankara, Turkey. |
Glucocorticoids have been used in chemotherapy regimens of leukemia for their lymphocytic effect. Glucocorticoid resistances (GC) remain as an important problem and the exact mechanism has not been elucidated. Many studies have been reported describing the relation between response and Glucocorticoid Receptors α/β (GR α/β) expression in childhood leukemia. In present study aimed to determine expression levels of glucocorticoid receptors and to evaluate the relationship with clinical parameters and development of glucocorticoid resistance in children with acute leukemia. To test this hypothesis, GRα/β messenger-RiboNucleic Acid (m-RNA) expression levels were determined in 13 children wtih acute leukemia patients. This study ‘results reported that GRβ expression levels were high at leukemia. The results in this article seem to be the first screening results of the GRα/β m-RNA expression levels studied by quantitative Real Time Polymerase Chain Reaction (qRT- PCR) in Turkish acute leukemia patients. The cause of GC resistance in childhood leukemia is largely unknown. The clinical glucocorticoid resistance positivity and the GRα/β ratio may be effective in leading leukemia in glucocorticoid resistance.
Keywords
Glucocorticoid Receptor, Leukemia, Glucocorticoid Resistance
Reference
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