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AASCIT Journal of Bioscience

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Amelioration of Some Indices of Diabetic Complications Using Senna occidentalis Leaf Extract in Alloxan-Induced Diabetes in Rats

AASCIT Journal of Bioscience
Vol.3 , No. 4, Publication Date: Aug. 30, 2017, Page: 24-28

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Authors

[1]	Ojochenemi Ejeh Yakubu, Department of Biochemistry, Faculty of Pure and Apllied Sciences, Federal University Wukari, Wukari, Nigeria.

Abstract

This study was designed to investigate the ameliorative effects of some indices of diabetic complications using Senna occidentalis leaf extract in alloxan-induced diabetes in rats. Thirty male Wistar rats with body weight ranging from 150–200 g were selected for the study. Diabetes was induced by single intraperitoneal dose of alloxan injection (150 mg/ kg body weight). Rats were treated orally using aqueous and ethanol extracts of Senna occidentalis leaves at 100 mg/kg body weight once daily for 21-days. The fasting blood sugar (FBS), Thiobarbituric acid Reactive Substance (TBARS), alkaline Phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were analysed spectrophotometrically. The result of the study showed that treatment of diabetic rats with the extract caused significant (p<0.05) decrease in FBS, TBARS, ALP, ALT and AST. The result of study showed to a large extent the effects of Senna occidentalis in the amelioration of some complications resulting from diabetes.

Keywords

Senna occidentalis, Biochemical Complications, Diabetes

Reference

[01]	Haffner SM, Alexander CM, Cook JJ. (1999). Scandinavian Simvastatin Survival Study Group. Reduced Coronary events in simvastatin- treated patients with coronary heart disease and diabetes or impaired fasting glucose levels, sub group analysis from simvastatin survival study. Arch intern Me. 159: 2661-2677.
[02]	Goldberg RB, Melllies MJ, Sacks FM. (1998). Cardiovascular events and their reduction with Pravastatin in diabetic and glucose intolerant myocardial infarction. Survivors with average cholesterol levels: Sub group analysis in the cholesterol and recurrent events. Care investigators. 98: 2513-2519.
[03]	Lyons JJ, Jenkins AJ, Zheng D, Lackland DT, McGee D, Gavey WT. (2004). Diabetic retinopathy and serum lipoprotein subclasses in DCCT/EDIC Cohort. Invest Opthalmol Vis Sci. 45(3): 910-918.
[04]	Tesfaye S, Chaturvedi N, Eaton SE, Ward JD, Manes C, Ionescu-Tirgoviste G, Witte DR, Fuller JH. (2005). Vascular risk factors and diabetic neuropathy. N Engl J. Med. 352(18):1925-1927.
[05]	McGill HC, McMahan CA, Zieske AW, Sloop GD, Walcott JV, Troxclair DA. (2000). Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosisin youth. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Arterioscler Throm Vasc Biol. 20: 1998-2004.
[06]	Li TY, Hu FB, Colditz GA, Willet WC, Manson JE. (2003). Television watching and other sedentary behaviours in relation to risk of obesity and type 2 diabetes mellitus in women. JAMA. 298(14):1785-1791.
[07]	Ibrahim SS, Rizk SM. (2008). Nicotinamide: a cytoprotectant against streptozotocin-induced diabetic damage in wistar rat brains. Afr. J. Biochem. Res. 2(8):174-180.
[08]	Feillet-Coudray C, Rock E, Coudray C, Grzelkowska K, Azais-Braesco V, Dardevet D. (1999) Lipid peroxidation and anti-oxidant status in experimental diabetes. Clin. Chim. Acta. 284:31-43.
[09]	Kakkar R, Mantha SV, Radhi J, Prasad K, Kalra J. (1997). Antioxidant defence system in diabetic kidney: A time course study. Life Sci. 60:667-679.
[10]	Obresova IG, Fathalah L, Lui E, Nourooz-Zadeh J. (2003). Early oxidative stress in diabetic kidney: effect of DL-α-lipoic acid. Free Radic. Biol. Med. 34:186-195.
[11]	Ugochukwu NH, Babady NE, Cobourne MK, Gasset SR. (2003). The Effect of Gongronema latifolium Extracts on Serum Lipid Profile and Oxidative Stress in Hepatocytes of Diabetic Rats. J. Biosci. 28(1):1-5.
[12]	Sexena DP, Shukla SK, Kumar R. (2011). Efficacy studies of In vitro screening of antiplasmodial activity by crude extracts of Diospyros melanoxylem plant Res. J. Med. 5:312-320.
[13]	Ohaeri CC, Eluwa MC. (2011). Abnornal biochemical and hematological indices in trypanosomiasis as a threat to herd production. Vet. Parasitol. 177:199-202.
[14]	U. S. Renal Data System, (USRDS). (2002). Annual data report; atlas of end-stage renal disease in the united states, national institutes of health, national institute diabetes and digestive and kidney diseases, Bethesda, MD.
[15]	Thomas M, Tsalamandris C, MacIsaac R, Jerums G. (2005). Anaemia in diabetes: An emerging complication of microvascular disease. Curr. Diabet. Rev. 1:107-126.
[16]	Momoh J, Akoro SM, Godonu KG. (2014). Hypoglycemic and Hepatoprotective Effects of Vernonia amygdalina (Bitter Leaf) and its effect on some biochemical parameters in alloxan-induced diabetic male albino rats. Science Journal of Biochemistry. 194 (10):7237-7244.