AASCIT - Journal - All Issues

ISSN: 2375-3900

American Journal of Pharmacy and Pharmacology

The Journal

Manuscript Information

Anti-proliferative Active Flavonoids from the Methanol Extract of Indian Herb Artimisia reticulata

American Journal of Pharmacy and Pharmacology
Vol.5 , No. 4, Publication Date: Aug. 10, 2018, Page: 27-32

2024 Views Since August 10, 2018, 747 Downloads Since Aug. 10, 2018

Paper in PDF (587K)

Follow on

Authors

[1]	Ajoy Kumar Bauri, Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai, India.
[2]	Peggy Jane Brodie, Department of Chemistry, Virginia Tech, Blacksburg, USA.
[3]	Sabine Foro, Institute of Materials Science, Darmstadt University of Technology, Darmstadt, Germany.
[4]	Nhu Quynh Nguyen Do, Accident and Emergency Department, Franco Vietnamese Hospital, Ho Chi Minh City, Vietnam.

Abstract

Fractionations of defatted methanol extract of herb Artemisia reticulata have led to isolation of a series of flavonoids (1-5). Anti-proliferative assay of these flavonoids was carried out against A2780 human ovarian cancer cell lines to compare with the prescribed drug taxol. Amongst these five flavonoids, compound (4) exhibited maximum anti-proliferative activity against the above cell lines. The structure of the compounds was established by combination of the ¹H and ¹³C NMR spectrum, EIMS analysis and was confirmed by X-ray diffraction study.

Keywords

Flavonoids, Artemisia reticulata, Anti-proliferative Activity

Reference

[01]	Khare CP (2008). Indian Medicinal Plants, page 64-65; Springer-Verlag Heidelberg Publishers
[02]	Bora KS, Sharma A (2010). Phytochemical and Pharmacological potential of Artemisa absinthium & Artemisia asiatica Nakai. J. Pharm. Res. 3 (2), 325-28.
[03]	Liu JM, Ni MY, Fan JF, Tu YY, Wu ZH, Qu YL, Chou MS (1979). Acta Chim. Sinica, 37, 129-143.
[04]	Androutsopoulous VP, Li N, Arroo RRJ (2009). J. Nat. Prod. 72, 1390-1394.
[05]	Dhingra V, Rao V, Narasu ML (2000). Life Sci., 66 (4), 279-300.
[06]	WHO report on implementation of global malaria control strategy (1993-2000). Technical Report Series No. 839, World Health Organization, ISBN 13: 9789241208390, order no. 11000839, WHO. Press Editions de I’MOS-Edicones de la OMS.
[07]	Flavonoids: Chemistry, Biochemistry and applications Edited by Oyvind Anderses, University of Bergen, Norway; Kenneth R Markham, industrial Research Ltd Lower Hutt, New Zealand.
[08]	Flavonoids and Heart Health: Proceedings of the ILSI North America Flavonoid Work shop, May 31-June 1, (2005), Washington (USA).
[09]	Teillet F, Boumendjel A, Boutonnat J, Ronot X (2007). Med. Res. Rev. 28 (5), 715-7.
[10]	Yanling L, Hao F, Wenfang X (2007). Recent advance in the research of flavonoids anticancer agents. Mini Review in Medicinal Chemistry 7, 663-678.
[11]	Kaul TN, Middleton Jr MD, Ogra PL (2005). Flavonoid as Anti-viral agent: J. Med. Viro. 15, 71-79.
[12]	Lopez LM (2002). Curr. Med. Chem. 2 (6), 691-714.
[13]	Brieskorn CH, Biechele W (1971). Deut Apoth Ztg 111, 141; Anal Abstra. 214404.
[14]	US Patent No. 06506792 (2003). Inventor: Reed, Michel John. London, United Kingdom Pott; Barry Victor Lloyd, Bath, United Kingdom, 2003/1/14/2000/8/14.
[15]	Sonmez UDB, Selcuk T, Osman O, Ufuk K, Gulacti T, Ayhan U (2005). Vascular Pharmacology 43, 220-226.
[16]	Ren W, Qiao Z, Wang H, Zhu L, Zhang L (2003). Med. Res. Rev. 23519-534.
[17]	Waldi D (1965). Spray Reagents for Thin Layer Chromatography Academic Press, New York, page 501.
[18]	Dean FM (1963). Naturally Occurring Oxygen Ring Compounds. Butterworth & Co Ltd., London, pp. 288-89.
[19]	Mabry TJ, Markham KR, Thomas MB (1970). The Systematic Identification of Flavonoids. Springer-Verlag, New York, pp. 36-38.
[20]	Horie T, Ohtsuru Y, Shibatat K, Yamashita K, Tsukamaya M, Kawamukat Y (1998). Phytochemistry 41, 865-874
[21]	Cao S, Brodie PJ, Randrianaivo R, Ratovoson F, Callmander M, Andriantsiferana R, Rasamison VE, Kingston DGI (2007). J. Nat. Prod. 70, 679-681.
[22]	Tarawneh A, Leon F, Pettaway S, Elokely KM, Klein ML, Lambert J, Mansoor A, Cutler SJ (2015). J. Nat. Prod. 78, 14611465.