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Vol.2 , No. 5, Publication Date: Feb. 26, 2016, Page: 72-78
 wistar rats of both sexes weighing between 100.5g-149.5g were divided into nine groups of four rats each. Group 1 received distilled water, while groups 2-5 and 6-9 received 400, 600, 800, and 1000mg/kg BW of extract for 7 and 14 days respectively. Rats were sacrificed 24hours after the last treatment and blood samples collected for determination of total cholesterol(T-CHOL), triglyceride(TG), high density lipoprotein-cholesterol(HDL-CHOL) and low density lipoprotein-cholesterol(LDL-CHOL), histological investigation on the heart tissue and phytochemical screening of the plant. Significant reductions (p<0.05) were observed in T-CHOL and TG in all the extract-treated groups when compared to control value and non significant reduction(p>0.05) HDL-CHOL and LDL-CHOL in all the groups except in groups 3 and 5 respectively. Phytochemical screening of plant revealed the presence of flavonoids, triterpenoids, saponins, tannin, steroid, cardiac glycoside and phenol in decreasing order (32.19±0.23, 26.24±0.12, 23.74±0.20, 18.74±0.17, 16.53±0.12, 15.28±0.23 and 13.10±0.11 mg/100g respectively).Histological result revealed that all heart muscles were in good histological conditions in control and all extract treated groups. Hence, aqueous whole plant extract of <i>selaginella myosurus</i> has hypolipidemic effect, could protect the heart against cardiovascular disease (CVD) and hence a promising potential herbal pharmaceutical agent.&picture=http://www.aascit.org/aascit/decorators/img/journal/922.jpg)
| [1] | Omeodu S. I., Department of Biochemistry, Faculty of Science, University of Port Harcourt, Rivers State, Nigeria. |
| [2] | Peters D. E., Department of Biochemistry, Faculty of Science, University of Port Harcourt, Rivers State, Nigeria. |
| [3] | Oki J., Department of Biochemistry, Faculty of Science, University of Port Harcourt, Rivers State, Nigeria. |
Cardiovascular disease continues to be the leading cause of death across the globe today. Treatment with synthetic drugs is associated with several adverse effects. This study was designed to investigate the effect of aqueous whole plant extract of selaginella myosurus on lipid profile of wistar rats. A total of thirty six (36) wistar rats of both sexes weighing between 100.5g-149.5g were divided into nine groups of four rats each. Group 1 received distilled water, while groups 2-5 and 6-9 received 400, 600, 800, and 1000mg/kg BW of extract for 7 and 14 days respectively. Rats were sacrificed 24hours after the last treatment and blood samples collected for determination of total cholesterol(T-CHOL), triglyceride(TG), high density lipoprotein-cholesterol(HDL-CHOL) and low density lipoprotein-cholesterol(LDL-CHOL), histological investigation on the heart tissue and phytochemical screening of the plant. Significant reductions (p<0.05) were observed in T-CHOL and TG in all the extract-treated groups when compared to control value and non significant reduction(p>0.05) HDL-CHOL and LDL-CHOL in all the groups except in groups 3 and 5 respectively. Phytochemical screening of plant revealed the presence of flavonoids, triterpenoids, saponins, tannin, steroid, cardiac glycoside and phenol in decreasing order (32.19±0.23, 26.24±0.12, 23.74±0.20, 18.74±0.17, 16.53±0.12, 15.28±0.23 and 13.10±0.11 mg/100g respectively).Histological result revealed that all heart muscles were in good histological conditions in control and all extract treated groups. Hence, aqueous whole plant extract of selaginella myosurus has hypolipidemic effect, could protect the heart against cardiovascular disease (CVD) and hence a promising potential herbal pharmaceutical agent.
Keywords
Total Cholesterol (T-CHOL), Triglyceride (TG), Low Density Lipoprotein Cholesterol (LDL-CHOL) and High Density Lipoprotein Cholesterol (HDL-CHOL)
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