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Vol.2 , No. 4, Publication Date: Oct. 8, 2015, Page: 45-51
, enlisted in World Health Organization (WHO) Essential Drugs List (EDL) and common for children in liquid formulations is a widely used analgesic/antipyretic for all ages, especially in reducing post-vaccination fever in infants/toddlers. Its paediatric dose is sometimes calculated from the adult formula by health professionals based on its concentration in mg/kg of body weight. This is not always realistic for parents or care-givers to manage at home, especially among the unenlightened class. Children of very wide varying age bracket may receive the same dose for the fact that single paediatric dose of PCM in tablet form is not popular. This study evaluates a co-processed filler-binder-super disintegrant based on edible mushroom, <i>Lentinus tuber regium</i> incorporated to trigger rapid dispersion of a paediatric dispersible tablet (PDT) containing 125 mg of PCM prepared by solvent evaporation of alcoholic wet massed excipients. Granules obtained were free from enteric or pathogenic organisms, flowable, compressible and its compression resulted to tablets with crushing strength, 30. 60 ± 1. 01 N; friability, 0. 20 ± 0. 01 % and crushing strength friability ratio (CSFR), 153. 00. Uniform and complete dispersion of the PDT occurred in 28 s in 10 ml of water at 27 ± 2℃. A spectrophotometric assay of the entire dispersion yielded 120. 99±0. 84 mg of PCM in vitro. It is hoped that this portable and easily dispersible single paediatric dose of PCM tablet will reduce the pains and sometimes, inaccuracies incurred in calculating paediatric doses of PCM from adult formula, especially among the unenlightened care-givers.&picture=http://www.aascit.org/aascit/decorators/img/journal/922.jpg)
| [1] | Ugoeze K. C., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Nigeria. |
| [2] | Nwachukwu N., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Nigeria. |
| [3] | Ibezim C. N. E., Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Nigeria. |
Paracetamol (PCM), enlisted in World Health Organization (WHO) Essential Drugs List (EDL) and common for children in liquid formulations is a widely used analgesic/antipyretic for all ages, especially in reducing post-vaccination fever in infants/toddlers. Its paediatric dose is sometimes calculated from the adult formula by health professionals based on its concentration in mg/kg of body weight. This is not always realistic for parents or care-givers to manage at home, especially among the unenlightened class. Children of very wide varying age bracket may receive the same dose for the fact that single paediatric dose of PCM in tablet form is not popular. This study evaluates a co-processed filler-binder-super disintegrant based on edible mushroom, Lentinus tuber regium incorporated to trigger rapid dispersion of a paediatric dispersible tablet (PDT) containing 125 mg of PCM prepared by solvent evaporation of alcoholic wet massed excipients. Granules obtained were free from enteric or pathogenic organisms, flowable, compressible and its compression resulted to tablets with crushing strength, 30. 60 ± 1. 01 N; friability, 0. 20 ± 0. 01 % and crushing strength friability ratio (CSFR), 153. 00. Uniform and complete dispersion of the PDT occurred in 28 s in 10 ml of water at 27 ± 2℃. A spectrophotometric assay of the entire dispersion yielded 120. 99±0. 84 mg of PCM in vitro. It is hoped that this portable and easily dispersible single paediatric dose of PCM tablet will reduce the pains and sometimes, inaccuracies incurred in calculating paediatric doses of PCM from adult formula, especially among the unenlightened care-givers.
Keywords
Paediatric, Dispersible, Paracetamol, Lentinus tuber regium, Co-processed, Filler-Binder-Superdisintegrant
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