ISSN: 2375-379X
Health Sciences Research  
Manuscript Information
 
 
Nitrosative Stress in Skeletal Muscle of Diabetic Rats Submitted to Aerobic Exercise
Health Sciences Research
Vol.4 , No. 6, Publication Date: Oct. 17, 2017, Page: 57-63
128 Views Since October 17, 2017, 49 Downloads Since Oct. 17, 2017
 
 
Authors
 
[1]    

Deyse Yorgos Lima, Translational Medicine, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.

[2]    

Adelson Marçal Rodrigues, Translational Medicine, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.

[3]    

Giovana Rita Punaro, Nephrology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.

[4]    

Margaret Gori Mouro, Translational Medicine, Universidade Federal de Sao Paulo, Sao Paulo, Brazil; Nephrology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.

[5]    

Elisa Mieko Suemitsu Higa, Translational Medicine, Universidade Federal de Sao Paulo, Sao Paulo, Brazil; Nephrology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.

 
Abstract
 

The aim of this study was to assess the nitrosative stress in muscle tissue of diabetic rats submitted to aerobic training. Diabetes mellitus was induced by streptozotocin in male adult Wistar rats. The animals were submitted to aerobic training on treadmill and after 8 weeks, the gastrocnemius was removed for analysis. Data are shown as mean ±SEM; statistical analysis by One-Way ANOVA, with significance at p<0.05. DM+SE when compared with CTL+SE showed a reduction of body weight followed by other changes as increased chow and water intake, diuresis, glycemia and TBARS in the muscle. There was a significant improvement in all metabolic parameters in the trained diabetic animals when compared to the untrained; moderate exercise in diabetic animals reduced significantly the lipoperoxidation in the muscle. There was also an increase of superoxide anion and antioxidant defenses; this defense neutralized the action of anion, shown by reduction of the nitrotyrosine levels. Therefore, the results show that moderate exercise promotes benefits to the skeletal muscle, reducing the diabetic complications i.e., the oxidative stress, the glutathionylation and the nitrosative stress. It is suggested, that the aerobic training can be an adjuvant treatment, which could enhance the life quality of diabetic patients.


Keywords
 

Diabetes, Gastrocnemius, Glutathionylation, Nitrosative/Oxidative Stress


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