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Histopathological Studies on Fatty Liver Disease

Health Sciences Research
Vol.4 , No. 6, Publication Date: Sep. 26, 2017, Page: 41-45

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Authors

[1]	Mahmoud Gomaa, Microbiology Section, Faculty of Science, Tanta University, Tanta, Egypt.
[2]	Mostafa Mohamed El-Sheekh, Microbiology Section, Faculty of Science, Tanta University, Tanta, Egypt.
[3]	Ahmed S. El-Shafey, Microbiology Section, Faculty of Science, Tanta University, Tanta, Egypt.
[4]	Saied Mohamed Hamad, Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt.

Abstract

The present study was conducted to evaluate the efficiency of natural Spirulina preparation in on fatty liver. The histopathological examinations were done in rats at the start, with normal diet, after induction of fatty liver (naturally and chemically) and after using different Spirulina concentration in the diet after 1, 2 and 3 weeks. This study proved that Spirulina has effect for regulation of fat metabolism of fatty liver.

Keywords

Fatty Liver, Histopathological Examinations, Diet, Spirulina

Reference

[01]	Bayard M, Holt J and Boroughs E (2006): "Nonalcoholic fatty liver disease". American family physician 73 (11): 1961-1968.
[02]	Riely CA (1987): Acute fatty liver of pregnancy, Semin. Liver Dis. 7 (1): 47-54.
[03]	Doherty JF, Golden MH and Brooks SE (1991): Peroxisomes and the fatty liver of malnutrition: A hypothesis. Am. J. Clin. Nutr.; 54, 674.
[04]	Guha-Mazumder DN (2001): Arsenic and liver disease, J. Indian Med. Assoc. 99: 311-324.
[05]	Yu AS and Keeffe EB (2002): Nonalcoholic fatty liver disease, Rev. Gastroenterol. Disord. 2: 11-16.
[06]	Altlparmak E, Koklu S, Yallnklllc M, Yuksel O, Cicek B, Kayacetin E and Sahin T (2005): Viral and host causes of fatty liver in chronic hepatitis B. World J. Gastroenterol.; 11: 3056-3059.
[07]	Adams LA and Talwalkar JA (2006): Diagnostic evaluation of nonalcoholic fatty liver disease, J. Clin. Gastroenterol; 40: 34-65.
[08]	Reddy JK and Rao MS (2006): "Lipid metabolism and liver inflammation, Fatty liver disease and fatty acid oxidation". Am. J. Physiol. Gastrointest. Liver Physiol. 290 (5): 852–858.
[09]	Rodríguez-Hernández A, Blé-Castillo JL, Juárez-Oropeza MA and Díaz-Zagoya JC (2001): Spirulina maxima prevents fatty liver formation in CD-1 male and female mice with experimental diabetes, Life Sci. 69: 1029-1037.
[10]	Samuels R, Mani UV and Iyer UM (2002): Hypocholesterolemic effect of Spirulina in patients with hyperlipidemic nephritic syndrome, J. Med. Food 5: 91.
[11]	Iwasa M, Yamamoto M, Tanaka Y, Kaito M and Adachi Y (2002): Spirulina-associated hepatotoxicity, Am. J. Gastroenterol.; 97: 3212-3213.
[12]	Pereira JN and Jangaard NO (1971): Different rates of glucose and fructose metabolism in rat liver tissue in vitro, Metabolism 20: 392.
[13]	Iwata K, Inayama T and Kato T (1990): Effects of Spirulina platensis on plasma lipoprotein lipase activity in fructose-induced hyperlipidemic rats. J. Nutr. Sci. Vitaminol. (Tokyo); 36: 165–171.
[14]	Torres-Duran PV, Miranda-Zamora R, Paredes-Carbajal MC, Mascher D, Diaz-Zagoya JC and Oropeza J (1998): Spirulina maxima prevent induction of fatty liver by carbon tetrachloride in the rat. Biochem. Mol. Biol. Int. 44: 787-793.
[15]	Blé-Castillo JL, Rodríguez-Hernández A, Miranda-Zamora R, Juárez-Oropeza MA, and Díaz-Zagoya JC (2002): Arthrospira maxima prevent the acute fatty liver induced by the administration of simvastatin, ethanol and a hypercholesterolemic diet to mice, Life Sci. 70: 2665-2673.
[16]	Rodríguez-Hernández A, Blé-Castillo JL, Juárez-Oropeza MA and Díaz-Zagoya JC (2001): Spirulina maxima prevents fatty liver formation in CD-1 male and female mice with experimental diabetes, Life Sci. 69: 1029-1037.
[17]	Tanaka F, Shiratori Y, Yokosuka O, Imazeki F, Tsukada Y, Omata M (1996): High incidence of ADH21/ALDH21 gene among Japanese alcohol dependents and patients with alcoholic liver disease. Hepatology; 23: 234-239.
[18]	Chao YC, Wang LS, Hsieh TY and Chu CW (1997): Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients. Hepatology.; 25: 112-117.
[19]	Gorban EM, Orynchak MA, Virstiuk NG, Kuprash LP, Panteleimonov TM, Sharabura LB (2000): Clinical and experimental study of Spirulina efficacy in chronic diffuse liver diseases. Lik Sprava; (6): 89-93.
[20]	Young DS (2001): Effects of disease on Clinical Lab. Tests, 4th ed AACC.
[21]	Young DS (1995): Effects of drugs on Clinical Lab. Tests, 4th ed AACC Press.
[22]	Tietz NW (1995): Clinical Guide to Laboratory Tests, 3" Edition. W. B. Saunders Co. Philadelphia, PA.
[23]	Lowe J (1995): Histopathology stain handbook, university of Nottingham medical school.
[24]	Angulo P (2002): Nonalcoholic fatty liver disease. N. Engl. J. Med.; 346 (16): 1221-1231.
[25]	Aldo Ferreira-Hermosillo, Patricia V Torres-Duran, and Marco A Juarez-Oropeza: (2010): Hepatoprotective effects of Spirulina maxima in patients with non-alcoholic fatty liver disease: a case series; J Med Case Reports. 4: 103.