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Vol.3 , No. 2, Publication Date: Apr. 21, 2016, Page: 17-22
 in ameliorating the toxic effect of Aluminium on the kidney of male wistar rats was investigated. Forty eight male wistar rats (100-175g) were divided into eight equal groups of six rats each and the mean weight for each group was taken. Normal drinking water and feed was given to the control group, while the other seven groups 2- 8 received 200mg/kg b.w of aluminium (Al) daily. Group 2 received only Al. Groups 3 - 8 were administered orally with zinc, selenium, ginseng, vitamin A, vitamin C, vitamin E respectively at doses 14.8mg/kg b.w, 100mg/kg b.w, 10mg/kg b.w, 100mg/kg b.w, 100mg/kg b.w, 100mg/kg b.w for 6 weeks. Administration of Al showed a significant increase (p<0.05) in the creatinine, urea and electrolyte levels, while administration of zinc, selenium, ginseng, vitamin A, vitamin C, and vitamin E ameliorated the toxic effect of aluminium when compared to the control value. Histopathological investigation of kidney of rats in the control group showed a normal architecture of kidney cells whereas the administration of Aluminium caused distortion of the renal tubular cells. Investigation of Aluminium + Antioxidant groups; the Al+Zinc, Al+Ginseng, Al+Vit A, Al+Vit C, Al+Vit E showed no obvious histological changes. However, the group treated with selenium showed a mild tubular distortion, this shows that selenium was not able to completely ameliorate the toxic effect of aluminium. This investigation showed that zinc, ginseng, vitamin A, vitamin C, and vitamin E have beneficial influences and are able to ameliorate aluminium toxicity in the kidney of male wistar rats.&picture=http://www.aascit.org/aascit/decorators/img/journal/908.jpg)
| [1] | Onyegeme-Okerenta B. M., Department of Biochemistry, Faculty of Science, University of Port Harcourt, Choba, Rivers State, Nigeria. |
| [2] | Anacletus F. C., Department of Biochemistry, Faculty of Science, University of Port Harcourt, Choba, Rivers State, Nigeria. |
The effectiveness of selected antioxidants supplements (zinc, selenium, ginseng, vitamin A, vitamin C, and vitamin E) in ameliorating the toxic effect of Aluminium on the kidney of male wistar rats was investigated. Forty eight male wistar rats (100-175g) were divided into eight equal groups of six rats each and the mean weight for each group was taken. Normal drinking water and feed was given to the control group, while the other seven groups 2- 8 received 200mg/kg b.w of aluminium (Al) daily. Group 2 received only Al. Groups 3 - 8 were administered orally with zinc, selenium, ginseng, vitamin A, vitamin C, vitamin E respectively at doses 14.8mg/kg b.w, 100mg/kg b.w, 10mg/kg b.w, 100mg/kg b.w, 100mg/kg b.w, 100mg/kg b.w for 6 weeks. Administration of Al showed a significant increase (p<0.05) in the creatinine, urea and electrolyte levels, while administration of zinc, selenium, ginseng, vitamin A, vitamin C, and vitamin E ameliorated the toxic effect of aluminium when compared to the control value. Histopathological investigation of kidney of rats in the control group showed a normal architecture of kidney cells whereas the administration of Aluminium caused distortion of the renal tubular cells. Investigation of Aluminium + Antioxidant groups; the Al+Zinc, Al+Ginseng, Al+Vit A, Al+Vit C, Al+Vit E showed no obvious histological changes. However, the group treated with selenium showed a mild tubular distortion, this shows that selenium was not able to completely ameliorate the toxic effect of aluminium. This investigation showed that zinc, ginseng, vitamin A, vitamin C, and vitamin E have beneficial influences and are able to ameliorate aluminium toxicity in the kidney of male wistar rats.
Keywords
Aluminium, Antioxidants, Creatinine, Electrolyte, Nephrotoxicity, Urea, Wistar Rats
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