Indexing
All Issues
Submission
Author Guidelines
Reviewers
Editorial Members
Publication Fee
Vol.3 , No. 3, Publication Date: Apr. 21, 2016, Page: 30-34
 were used and grouped into eight groups (control, aluminium, zinc, selenium, ginseng, vitamin A, vitamin C and vitamin E) and were allowed to acclimatize in their new environment for 21days. Administration of the aluminium and antioxidants started immediately. Group 1 was the control and no chemical was administered, group 2 was administered 200mg/kg of aluminium alone while groups 3-8 were administered zinc, selenium, ginseng, vitamin A, vitamin C and vitamin E alongside aluminium with dosages of 14.8mg/kg, 100mg/kg, 10mg/kg, 100mg/kg, 100mg/kg,100mg/kg and 200mg/kg respectively. The animals were exposed to treatments once daily for six weeks after which the animals were sacrificed and blood samples were collected and analyzed in the laboratory. Results obtained showed significant increase (p<0.05) in the concentration of cholesterol, triglycerides, HDL and LDL in the aluminium group when compared with that of the control group. The various antioxidants however significantly (p<0.05) ameliorated the effect of the aluminium toxicity by reducing the various concentration of cholesterol, triglycerides, LDL and increasing that of HDL. Similarly, there was significant decrease (p<0.05) in the haematological indices indicating thrombocytopenia, anaemia and leucopenia. However, co-administration of aluminium and antioxidants especially vitamins C and E resulted in significant increase (p<0.05) in the haematological indices.&picture=http://www.aascit.org/aascit/decorators/img/journal/908.jpg)
| [1] | Anacletus F. C., Department of Biochemistry, Faculty of Science, University of Port Harcourt, Choba, Rivers State, Nigeria. |
| [2] | Onyegeme-Okerenta B. M., Department of Biochemistry, Faculty of Science, University of Port Harcourt, Choba, Rivers State, Nigeria. |
This study evaluated the changes on haematology indices and lipid profile of aluminium-induced toxicity and ameliorative effects of selected antioxidants on wistar rats. Ninety-six wistar rats (48 males and 48 females) were used and grouped into eight groups (control, aluminium, zinc, selenium, ginseng, vitamin A, vitamin C and vitamin E) and were allowed to acclimatize in their new environment for 21days. Administration of the aluminium and antioxidants started immediately. Group 1 was the control and no chemical was administered, group 2 was administered 200mg/kg of aluminium alone while groups 3-8 were administered zinc, selenium, ginseng, vitamin A, vitamin C and vitamin E alongside aluminium with dosages of 14.8mg/kg, 100mg/kg, 10mg/kg, 100mg/kg, 100mg/kg,100mg/kg and 200mg/kg respectively. The animals were exposed to treatments once daily for six weeks after which the animals were sacrificed and blood samples were collected and analyzed in the laboratory. Results obtained showed significant increase (p<0.05) in the concentration of cholesterol, triglycerides, HDL and LDL in the aluminium group when compared with that of the control group. The various antioxidants however significantly (p<0.05) ameliorated the effect of the aluminium toxicity by reducing the various concentration of cholesterol, triglycerides, LDL and increasing that of HDL. Similarly, there was significant decrease (p<0.05) in the haematological indices indicating thrombocytopenia, anaemia and leucopenia. However, co-administration of aluminium and antioxidants especially vitamins C and E resulted in significant increase (p<0.05) in the haematological indices.
Keywords
Aluminium, Toxicity, Haematology, Lipid, Antioxidants
Reference
| [01] | ATSDR (Agency for Toxic Substances and Disease Registry): (2005). “Toxicological profile for aluminum and compounds”. Atlanta, GA.: U. S Department of Health and Human Services, Public health service. |
| [02] | Wagner, W. (1999). “Canadian Minerals Year book”. Ottawa: Natural Resources Canada. |
| [03] | Abreo, V. (2015). The Dangers of Aluminium Toxicity. Bella Online's Alternative Medicine Editor. http://www.bellaonline.com/articles/art12624.asp. http:// www.bellaonline. Com/articles/ art7739.asp. |
| [04] | Exley, C., Charles, L. M., Barr, L., Martin, C., Polwart, A. & Darbre, P. D. (2007). "Aluminium in human breast tissue”. Journal of Inorganic Biochemistry101 (9):1344–6. |
| [05] | Lankoff, A., Banasik, A. & Duma, A. (2006). "A comet assay study reveals that aluminium induces DNA damage and inhibits the repair of radiation-induced lesions in human peripheral blood lymphocytes". Toxicology Letters, 161 (1): 27–36. |
| [06] | Graves, A. B., White, E., Koepsell, T. D., Reifler, B. V., van Belle, G. & Larson, E. B. (1990). "The association between Aluminium-containing products and Alzheimer's disease". Journal of Clinical Epidemiology 43 (1): 35–44. |
| [07] | Mahieu, S., Contini, M., Gonzalez, M., Millen, N. & Elias, M. M. (2000). Aluminum toxicity. Hematological effects. Toxicology Letters, 111: 235-242. |
| [08] | Zaman, K., Zaman, W. & Siddique, H. (1993). Hematological and enzymatic results of aluminum intoxication in rats. Comparative Biochemistry and Physiology, 105: 73-76. |
| [09] | Eschbach, J. W., Varma, A., & Stivelman, J. C. (2002). Is it time for a paradigm shift? Is erythropoietin deficiency still the main cause of renal anaemia? Nephrology Dialysis Transplantation, 17 (5): 2-7. |
| [10] | Fraga, C. G., Oteiza, P. I., Golub, M. S., Gerswin, M. E. & Keen, C. L. (1990). Effects of aluminium on brain lipid peroxidation. Toxicology Letters, 51: 213-219. |
| [11] | Salvemini, D. & Botting, R. (1993). Modulation of platelet function by free radicals and free radical scavengers. Trends in Pharmacological Sciences, 14: 36-42. |
| [12] | Dacie, J. V. & Lewis, S. M. (2006). Investigation of haematological disorders. Practical Haematology, Churchill Livingstone Edinburgh, United Kingdom, pp: 177-180. |
| [13] | Kritchersky, (1970). Role of cholesterol vehicle in experiment atherosclerosis. American Journal of Clinical Nutrition, 23: 1105-1110. |
| [14] | Salah, E. I., Sabahelkhier, M. K. & Shama, I. Y. Adam. (2015). Effects of aluminum sulphate treated in deionizable and tap water on lipid profile of wister rats. ARPN Journal of Science and Technology, 5(5): 268-270. |
| [15] | Thirunavukkarasu, C. & Sakthisekaran, D. (2003). Influence of sodium selenite on glycoprotein contents in normal and N-nitrosodiethylamine initiated and phenobarbital promoted rat liver tumors. Pharmacological Research 48: 167-173. |
| [16] | Samani, K. G., Farrokhi, E., Samani, N. M. & Moradi, H. H. (2015). The effect of Aluminum on the increasing risk of developing anemia among workers of tile production plants. International Journal of Epidemiologic Research, 2(1) 24-29. |
| [17] | Siess, M. H., Le Bon, A. M., Canivenc-Lavier, M. C. & Susch, M. (2000). Mechanisms Involved in the Chemoprevention of Flavonoids, Biofactor, 12 (4), 193-199. |
