ISSN: 2375-3838
International Journal of Clinical Medicine Research  
Manuscript Information
Use of Pre-emptive Vs. Reactive Management Strategies for Skin Toxicities Among mCRC Patients Treated with Panitumumab in the US
International Journal of Clinical Medicine Research
Vol.6 , No. 4, Publication Date: Aug. 22, 2019, Page: 31-38
304 Views Since August 22, 2019, 131 Downloads Since Aug. 22, 2019

Kimberly Lowe, Amgen, Inc, Thousand Oaks, California, USA.


Laura Sangaré, SimulStat, Portland, Oregon, USA.


Rachel Bergstresser, Adelphi Research, Doylestown, Pennsylvania, USA.


Kristina Hool, Amgen, Inc, Thousand Oaks, California, USA.


George Kafatos, Amgen, Ltd, United Kingdom.


Michelle McNamara, Adelphi Research, Doylestown, Pennsylvania, USA.


Tamer Garawin, Amgen, Inc, Thousand Oaks, California, USA.


Background: The study aimed to assess oncologist’s opinions and perceptions regarding the management of dermatologic toxicity among the patients they treat with panitumumab, with specific emphasis on the timing of rash management. Methods: A survey was developed in September 2016 based on the current literature and expert opinions regarding the management of dermatologic toxicities. Eligible oncologists were board certified and had treated at least five new or continuing patients with mCRC in the last three months, with at least three patients who received or were currently receiving panitumumab. Pre-emptive treaters were defined as those who reported treating≥50% of their panitumumab-treated patients prior to the onset of rash. The remaining oncologists were categorized as reactive treaters. Results: Among the 250 oncologists who completed the survey, 139 (56%) participants were categorized as pre-emptive treaters. A higher proportion of pre-emptive treaters than reactive treaters recommended every one of the specific management strategies that were assessed in the survey, including: skin moisturizer (78% vs. 58%; p<0.001), sunscreen (75% vs. 57%; p=0.002), over-the-counter (OTC) topical steroids (42% vs. 37%; p=0.27), prescription strength topical steroids (30% vs 30%; p=0.95), topical antibiotics (37% vs. 26%; p=0.001), oral antibiotics (39% vs. 26%; 0.006), and UV protective garments (61% vs. 47%; p=0.008). Conclusions: Our results clearly illustrate the urgent need for heightened education among oncologists who treat mCRC patients with panitumumab. Several management strategies, such as moisturizer, sunscreen, and UV protective garments, are easily implemented and should be recommended to 100% of mCRC patients who receive panitumumab.


Anti-EGFR, Panitumumab, Dermatologic Toxicity, Anceniform Rash, Metastatic Colorectal Cancer (mCRC)


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