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Vol.1 , No. 3, Publication Date: Aug. 26, 2014, Page: 90-96
| [1] | Abu-Hussein Muhamad, Department of Pediatic Dentistry, Athens, Greece. |
| [2] | Abdulgani Azzaldeen, Department of Conservative Dentistry, Al-Quds University, Jerusalem, Palestine. |
| [3] | Watted Nezar, Center of Dentistry & Esthetics, J att, Israel. |
| [4] | Kassem Firas, Department of Otolaryngology–Head and Neck Surgery, Meir Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel. |
Congenital cleft-Lip and cleft palate have been the subject of many genetic studies, but until recently there has been no consensus as to their modes of inheritance. In fact, claims have been made for just about every genetic mechanism one can think of. Recently, however, evidence has been accumulating that favors a multifactorial basis for these malformations. The purpose of the present paper is to present the etiology of cleft lip and cleft palate both the genetic and the environmental factors. It is suggested that the genetic basis for diverse kinds of common or uncommon congenital malformations may very well be homogeneous, whilst, at the same, the environmental basis is heterogeneous.
Keywords
Clef Lip, Cleft Palate, Etiology, Genetic, Multifactorial
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