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Vol.6 , No. 5, Publication Date: Nov. 12, 2019, Page: 39-44
. Objective: In this study, the relationship between the Diffusion Tensor Imaging (DTI) method and the SCOPA-Cog clinical test was investigated in different domains of cognitive impairment. Method: This study was performed on 20 patients with clinical diagnosis of idiopathic PD. Fractional anisotropy (FA) and mean diffusivity (MD) parameters were calculated by drawing region of interest (ROI) on 15 distinct areas. Cognitive impairment was evaluated using the SCOPA-Cog standard test. Conclusion: The results of investigation of the relationship between the DTI method and SCOPA-Cog clinical test showed that changes in FA and MD values in the Fornix area were significant compared to SCOPA test results. We found correlations between DTI parameters and executive function score in some regions such as Genu, superior fronto-occipital fasciculus (SFOF), anterior limb of internal capsule (ALIC) and posterior corona radiata (PCR). The results showed that there is a significant relationship between DTI parameters and visuospatial score in parieto-occipital domain. The results indicate that there is a correlation between DTI method and the SCOPA clinical test. This information can be used to measure sensitivity and reliability of SCOPA test in early detection of Parkinson's disease.&picture=http://www.aascit.org/aascit/decorators/img/journal/906.jpg)
| [1] | Elahe Hoseini, Radiology Technology Department, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. |
| [2] | Fariborz Faeghi, Radiology Technology Department, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. |
| [3] | Farzad Ashrafi, Neurology Brain Mapping Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. |
| [4] | Ali Hekmatnia, Department of Radiology, Esfahan University of Medical Sciences, Esfahan, Iran. |
Back ground: Cognitive impairments play an important role in Parkinson's disease (PD). Objective: In this study, the relationship between the Diffusion Tensor Imaging (DTI) method and the SCOPA-Cog clinical test was investigated in different domains of cognitive impairment. Method: This study was performed on 20 patients with clinical diagnosis of idiopathic PD. Fractional anisotropy (FA) and mean diffusivity (MD) parameters were calculated by drawing region of interest (ROI) on 15 distinct areas. Cognitive impairment was evaluated using the SCOPA-Cog standard test. Conclusion: The results of investigation of the relationship between the DTI method and SCOPA-Cog clinical test showed that changes in FA and MD values in the Fornix area were significant compared to SCOPA test results. We found correlations between DTI parameters and executive function score in some regions such as Genu, superior fronto-occipital fasciculus (SFOF), anterior limb of internal capsule (ALIC) and posterior corona radiata (PCR). The results showed that there is a significant relationship between DTI parameters and visuospatial score in parieto-occipital domain. The results indicate that there is a correlation between DTI method and the SCOPA clinical test. This information can be used to measure sensitivity and reliability of SCOPA test in early detection of Parkinson's disease.
Keywords
Cognitive Dysfunction, Parkinson Disease, Diffusion Tensor Imaging, White matter, Magnetic Resonance Imaging, Brain, Fractional Anisotropy, Mean Diffusivity
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