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Vol.5 , No. 3, Publication Date: May 16, 2018, Page: 61-66
. This case control study investigated the effects of malaria parasitaemia/HIV infection on packed cell volume, CD4+ T cell count and CD8 + T cell count of HIV pregnant women attending antenatal clinics (ANC) in three tertiary hospitals in Sokoto state, Nigeria. One hundred and three (103) HIV infected pregnant women participated in the study and were placed in two groups after performing malaria parasite identification and count. 45 HIV infected pregnant women served as the control subjects while 58 pregnant women coinfected with malaria and HIV served as the test subjects. All subjects were on antiretrovirals but didn’t know the line of drugs they were taking from the questionnaire administered. Packed cell Volume, CD4+ T cells and CD8+ T cells count were carried out by Microhaematocrit Method, BD FACS counter, and Enzyme Linked ImmunoSorbent Assay, respectively. There was no statistical significant between malaria and packed cell volume between the test and control group (p = 0.597) however the test subjects and control subjects had mean±sd of (31.62±3.12) and (31.39±2.69) respectively. There was a statistical association between Malaria and CD4 (p=0.00). Pregnant women with coinfection had significantly low CD4 as compared with the control counterparts, (425.45 ± 276.16) cells/mm<sup>3</sup> and (707.49 ± 212.94) cells/mm<sup>3</sup>. There was no statistical association between CD8 count of both the test and control groups (p= 0.21). MP/HIV coinfections exist in our study area especially in pregnant women. Without quick clinical interventions, cases of severe anemia will suffice, and low CD4+ T-cell count.&picture=http://www.aascit.org/aascit/decorators/img/journal/906.jpg)
| [1] | Chisom Emmanuel Okechukwu, Department of Medical Microbiology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [2] | Kabiru Mohammed, Department of Medical Microbiology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [3] | Eugene Ikeh, Department of Medical Microbiology, University of Jos Teaching Hospital, Jos, Nigeria. |
| [4] | Thompson Spencer, Department of Medical Microbiology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [5] | Ngwoke Clinton Chinedu, Department of Medical Microbiology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [6] | Idris Abdullahi Nasir, Department of Medical Laboratory Services, University of Abuja Teaching Hospital, Gwagwalada, FCT Abuja, Nigeria; Department of Medical Microbiology and Parasitology, College of Health Sciences, University of Ilorin, Ilorin, Nigeria. |
Malaria during pregnancy remains a serious public health problem especially in cases when there is a coinfection with Human Immunodeficiency virus (HIV). This case control study investigated the effects of malaria parasitaemia/HIV infection on packed cell volume, CD4+ T cell count and CD8 + T cell count of HIV pregnant women attending antenatal clinics (ANC) in three tertiary hospitals in Sokoto state, Nigeria. One hundred and three (103) HIV infected pregnant women participated in the study and were placed in two groups after performing malaria parasite identification and count. 45 HIV infected pregnant women served as the control subjects while 58 pregnant women coinfected with malaria and HIV served as the test subjects. All subjects were on antiretrovirals but didn’t know the line of drugs they were taking from the questionnaire administered. Packed cell Volume, CD4+ T cells and CD8+ T cells count were carried out by Microhaematocrit Method, BD FACS counter, and Enzyme Linked ImmunoSorbent Assay, respectively. There was no statistical significant between malaria and packed cell volume between the test and control group (p = 0.597) however the test subjects and control subjects had mean±sd of (31.62±3.12) and (31.39±2.69) respectively. There was a statistical association between Malaria and CD4 (p=0.00). Pregnant women with coinfection had significantly low CD4 as compared with the control counterparts, (425.45 ± 276.16) cells/mm3 and (707.49 ± 212.94) cells/mm3. There was no statistical association between CD8 count of both the test and control groups (p= 0.21). MP/HIV coinfections exist in our study area especially in pregnant women. Without quick clinical interventions, cases of severe anemia will suffice, and low CD4+ T-cell count.
Keywords
Gestational Malaria, Cellular Immunity, HIV/Malaria Coinfection, Nigeria
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