ISSN: 2375-3838
International Journal of Clinical Medicine Research  
Manuscript Information
Electroencephalogram and Brain CT-Scan Changes in Tramadol Associated Seizures
International Journal of Clinical Medicine Research
Vol.6 , No. 3, Publication Date: Jul. 23, 2019, Page: 23-27
134 Views Since July 23, 2019, 66 Downloads Since Jul. 23, 2019

Abbas Aghabiklooei, Department of Legal Medicine & Toxicology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.


Sedighe Sadat Erfani, Department of Legal Medicine & Toxicology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.


Objective: Drug-induced convulsions are the main causes of new-onset seizures and tramadol is one of the commonest drugs that can induced seizure. Methods: In a cross-sectional prospective survey, we assessed the predisposing factors, electroencephalogram (EEG) and brain computed tomography (CT) findings in tramadol-associated seizures cases. Results: of total of 126 drug-induced seizures, 26.2% were purely due to tramadol. Convulsion occurred after using a mean dose of 422 mg. Nearly 94% experienced only one single tonic-clonic convulsion. Brain CT scan was normal in all patients and non-epileptiform pattern were detected in eighty percent on EEG. Insomnia was the main risk factor related to convulsion. Conclusion: Although, head CT Scan has no rule in early treatment of drug induced seizure at ED, imaging is essential for rule out the concomitant trauma and other probable causes of new case of seizure even though in drug associated seizure.


Tramadol, Seizure, Brain CT Scan, Electroencephalogram


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