Vol.4 , No. 2, Publication Date: Jul. 5, 2017, Page: 15-20
[1] | Ke Xu, The Laboratory of Tropical Biomedicine Technology, and Faculty of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, China. |
[2] | Sufang Dong, The Laboratory of Tropical Biomedicine Technology, and Faculty of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, China. |
[3] | Ying Zhang, The Laboratory of Tropical Biomedicine Technology, and Faculty of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, China; Department of Medical Laboratory, Bazhou People’s Hospital, Korla, China. |
[4] | Qiang Wu, The Laboratory of Tropical Biomedicine Technology, and Faculty of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, China. |
[5] | Hua Pei, The Laboratory of Tropical Biomedicine Technology, and Faculty of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, China. |
[6] | Yingzi Lin, The Laboratory of Tropical Biomedicine Technology, and Faculty of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, China. |
[7] | Qianfeng Xia, The Laboratory of Tropical Biomedicine Technology, and Faculty of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou, China. |
Brucellosis remains prevalent in developing countries and results in substantial economic losses and human morbidity. The number of brucellosis cases increased in southeast Xinjiang provinces of China in recent years; however, the clinical epidemiological features of brucellosis in here are unclear. In this study, 160 patients with brucellosis in Bazhou People's Hospital between January 2014 and June 2015 were studied. The diagnosis was determined by clinical findings, and positive agglutination titer etc. Epidemiological investigation showed that Uighur ethnicity comprised 51.3% of all cases, and Han (37.5%), Mongolian (6.9%), Hui (3.1%), and Miao (1.3%). We divided all cases into four age groups: Junior (5.0%), adult 31.3%, middle-age 52.5% and senior 11.3%. Evidently, middle-age group was the majority. In additions, our investigation into the disease seasonal distribution showed the prevalence of brucellosis took place in summer months. According to the duration of symptoms, the investigated cases were grouped into acute (127 cases), sub-acute (27 cases), and chronic (6 cases) brucellosis. The most common symptom was fever (86.3%), followed by arthralgia (54.4%), headache (41.9%), sweating (27.5%) and cough (23.1%) etc. Taken together, the frequency of brucellosis appears to differ, depending on ethnicity, gender, season, age group, as well as involvement of professional occupation.
Keywords
Brucellosis, Epidemiological Features, Clinical Presentations, Retrospective Investigation
Reference
[01] | Queipo-Ortuno M I, Morata P, Ocon P, et al. Rapid diagnosis of human brucellosis by peripheral-blood PCR assay. J Clin Microbiol 1997; 35(11): 2927-30. |
[02] | Solera J, Martinez-Alfaro EEspinosa A. Recognition and optimum treatment of brucellosis. Drugs 1997; 53(2): 245-56. |
[03] | Franco M P, Mulder M, Gilman R H, et al. Human brucellosis. Lancet Infect Dis 2007; 7(12): 775-86. |
[04] | Gorvel J P. Brucella: a Mr "Hide" converted into Dr Jekyll. Microbes Infect 2008; 10(9): 1010-3. |
[05] | Wang W, Liao Q, Wu X, et al. Potential risk of blood transfusion-transmitted brucellosis in an endemic area of China. Transfusion 2015; 55(3): 586-92. |
[06] | Chen Z, Zhang W, Ke Y, et al. High-risk regions of human brucellosis in china: implications for prevention and early diagnosis of travel-related infections. Clin Infect Dis 2013; 57(2): 330-2. |
[07] | Zhong Z, Yu S, Wang X, et al. Human brucellosis in the People's Republic of China during 2005-2010. Int J Infect Dis 2013; 17(5): e289-92. |
[08] | Musallam, II, Abo-Shehada M N, Hegazy Y M, et al. Systematic review of brucellosis in the Middle East: disease frequency in ruminants and humans and risk factors for human infection. Epidemiol Infect 2016; 144(4): 671-85. |
[09] | Seleem M N, Boyle S MSriranganathan N. Brucellosis: a re-emerging zoonosis. Vet Microbiol 2010; 140(3-4): 392-8. |
[10] | Hasanjani Roushan M REbrahimpour S. Human brucellosis: An overview. Caspian J Intern Med 2015; 6(1): 46-7. |
[11] | Wise R I. Brucellosis in the United States. Past, present, and future. JAMA 1980; 244(20): 2318-22. |
[12] | Ganado WCraig A J. Brucellosis myelopathy. J Bone Joint Surg Am 1958; 40-A(6): 1380-8. |
[13] | Ulu-Kilic A, Metan GAlp E. Clinical presentations and diagnosis of brucellosis. Recent Pat Antiinfect Drug Discov 2013; 8(1): 34-41. |
[14] | Dean A S, Crump L, Greter H, et al. Clinical manifestations of human brucellosis: a systematic review and meta-analysis. PLoS Negl Trop Dis 2012; 6(12): e1929. |
[15] | Dean A S, Crump L, Greter H, et al. Global burden of human brucellosis: a systematic review of disease frequency. PLoS Negl Trop Dis 2012; 6(10): e1865. |
[16] | Buzgan T, Karahocagil M K, Irmak H, et al. Clinical manifestations and complications in 1028 cases of brucellosis: a retrospective evaluation and review of the literature. Int J Infect Dis 2010; 14(6): e469-78. |
[17] | Hasanjani Roushan M R, Mohrez M, Smailnejad Gangi S M, et al. Epidemiological features and clinical manifestations in 469 adult patients with brucellosis in Babol, Northern Iran. Epidemiol Infect 2004; 132(6): 1109-14. |
[18] | Pappas G, Papadimitriou P, Akritidis N, et al. The new global map of human brucellosis. Lancet Infect Dis 2006; 6(2): 91-9. |
[19] | Chen S, Zhang H, Liu X, et al. Increasing threat of brucellosis to low-risk persons in urban settings, China. Emerg Infect Dis 2014; 20(1): 126-30. |
[20] | Bikas C, Jelastopulu E, Leotsinidis M, et al. Epidemiology of human brucellosis in a rural area of north-western Peloponnese in Greece. Eur J Epidemiol 2003; 18(3): 267-74. |
[21] | Gotuzzo E, Alarcon G S, Bocanegra T S, et al. Articular involvement in human brucellosis: a retrospective analysis of 304 cases. Semin Arthritis Rheum 1982; 12(2): 245-55. |
[22] | Tasova Y, Saltoglu N, Sahin G, et al. Osteoarthricular involvement of brucellosis in Turkey. Clin Rheumatol 1999; 18(3): 214-9. |
[23] | Malik G M. A clinical study of brucellosis in adults in the Asir region of southern Saudi Arabia. Am J Trop Med Hyg 1997; 56(4): 375-7. |
[24] | Meky F A, Hassan E A, Abd Elhafez A M, et al. Epidemiology and risk factors of brucellosis in Alexandria governorate. East Mediterr Health J 2007; 13(3): 677-85. |
[25] | Smits H LKadri S M. Brucellosis in India: a deceptive infectious disease. Indian J Med Res 2005; 122(5): 375-84. |
[26] | Savas L O Y, Savas N, Yapar AF, Aydin M, Tugal O. Prospective evaluation of 140 patients with brucellosis in the southern region of Turkey. Infectious Diseases in Clinical Practice 2007; 15(2): 83-85. |
[27] | Lulu A R, Araj G F, Khateeb M I, et al. Human brucellosis in Kuwait: a prospective study of 400 cases. Q J Med 1988; 66(249): 39-54. |
[28] | Bennett J E D R, Blaser M J. Principles and practice of infectious diseases[M]. Elsevier Health Sciences, 2014. 2014. |
[29] | Demiroglu Y Z, Turunc T, Aliskan H, et al. [Brucellosis: retrospective evaluation of the clinical, laboratory and epidemiological features of 151 cases]. Mikrobiyol Bul 2007; 41(4): 517-27. |
[30] | Colmenero J D, Reguera J M, Martos F, et al. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 1996; 75(4): 195-211. |
[31] | Aygen B D M, Sümerkan B, et al.. Clinical manifestations, complications and treatment of brucellosis: a retrospective evaluation of 480 patients. Medecine et maladies infectieuses 2002; 32(9): 485-493. |
[32] | Mantur B G, Biradar M S, Bidri R C, et al. Protean clinical manifestations and diagnostic challenges of human brucellosis in adults: 16 years' experience in an endemic area. J Med Microbiol 2006; 55(Pt 7): 897-903. |
[33] | Kokoglu O F, Hosoglu S, Geyik M F, et al. Clinical and laboratory features of brucellosis in two university hospitals in Southeast Turkey. Trop Doct 2006; 36(1): 49-51. |
[34] | Young E J, Hasanjani Roushan M R, Shafae S, et al. Liver histology of acute brucellosis caused by Brucella melitensis. Hum Pathol 2014; 45(10): 2023-8. |