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Vol.3 , No. 1, Publication Date: Mar. 4, 2016, Page: 24-28
 in the Evolution of Cervical Dysplasia in HIV Positive Women in Nigeria&description=Objective: To ascertain the prevalence of cervical dysplasia and the relationship between the degree of cervical dysplasia and HAART in HIV- positive women. Method: This was a cross-sectional study involving 250 HIV positive women on HAART attending the HIV clinic of the University of Port Harcourt Teaching Hospital (UPTH). Cervical smears were collected from participants, examined and reported using the Bethesda system. Data was analysed using SPSS version 17 software package. Results: The prevalence of cervical dysplasia was 26.4%. CD4 count less than 500 cells/ul and HAART for less than 2 years were significantly associated with cervical dysplasia and high grade lesions. HIV positive women who were on HAART for less than 2 years were 3 and 7 times more likely to have cervical dysplasia and high grade lesions respectively. Conclusion: Abnormal CD4 count and shorter duration of HAART use were significantly associated with cervical dysplasia. The routine administration of HAART to HIV positive women irrespective of CD4 count may be beneficial.&picture=http://www.aascit.org/aascit/decorators/img/journal/906.jpg)
| [1] | Athanasius Boma Precious, Department of Anatomical Pathology, University of Port Harcourt Teaching Hospital, Port Harcourt, Rivers State, Nigeria. |
| [2] | Bassey Goddy, Department of Obstetrics and Gynaecology, University of Port Harcourt Teaching Hospital, Rivers State, Nigeria. |
Objective: To ascertain the prevalence of cervical dysplasia and the relationship between the degree of cervical dysplasia and HAART in HIV- positive women. Method: This was a cross-sectional study involving 250 HIV positive women on HAART attending the HIV clinic of the University of Port Harcourt Teaching Hospital (UPTH). Cervical smears were collected from participants, examined and reported using the Bethesda system. Data was analysed using SPSS version 17 software package. Results: The prevalence of cervical dysplasia was 26.4%. CD4 count less than 500 cells/ul and HAART for less than 2 years were significantly associated with cervical dysplasia and high grade lesions. HIV positive women who were on HAART for less than 2 years were 3 and 7 times more likely to have cervical dysplasia and high grade lesions respectively. Conclusion: Abnormal CD4 count and shorter duration of HAART use were significantly associated with cervical dysplasia. The routine administration of HAART to HIV positive women irrespective of CD4 count may be beneficial.
Keywords
Cervical Dysplasia, HAART, CD4-Count, Nigeria
Reference
| [01] | Kumar V, Abbas A, Fausto N. Robbins and Cotran Pathologic Basis of Disease 7th “ed” WB Saunder and Elsevier; 2006. 1073-1078. |
| [02] | Emembolu JO and Ekeme CG. Cancer of the cervix uteri in Zaria – Aetiological factors. Int J Gynecol Obstet. 1988; 26: 265-269. |
| [03] | UNAIDS. Global report: UNAIDS report on global AIDS epidemic 2010. www.unaids.org/documents/20101123. Global Report em.pdf. Published 2010. |
| [04] | Pereira DB, Antoni MH, Danielson A, Simon T, Efantis-Potter J, O’Sullivan MJ. Inhibited interpersonal coping style predicts poorer adherence to scheduled clinic visits in HIV infected women at risk for cervical cancer. Ann Behav Med. 2004; 28(3): 195-202. |
| [05] | Hawes SE, Critchlow CW, Sow PS, et al. Incident High grade squamous Intraepithelial lesion in Senegalese women with and without HIV type 1(HIV-1) and HIV-2. J Natl Cancer Inst. 2006 Jan 18; 98(2): 100-9. |
| [06] | Bagga R, Wanchi A, Rajwanshi A et al. Pap smear abnormalities in HIV infected in North India. Asia- Pac J Clin Oncol; 2005. 2-3: 77-80. |
| [07] | Gorna R. One hope, One world, One gender. J Int Assoc Physicians AIDS Care. 1996; 2(10): 28-30, 32-4. |
| [08] | Kreitchmann R, Bajotto H, daSilva DA, Fuchs SC. Squamous Intraepithelial lesions in HIV-infected women: prevalence, incidence, progression and regression. Arch Gynecol Obstet 2013; 288(5): 107-13. |
| [09] | Massad LS, Ahdieh L, Benning L, Minkoff H, Greenblatt RM, Watts H, et al. Evolution of cervical abnormalities among Women with HIV-1: evidence from surveillance cytology in women in the interagency HIV study. Journal of AIDS; 2001. 15; 27; (5): 432-42. Or AIDS; 2001. 15; 27; (5): 432-42. |
| [10] | Omar T, Schwartz S, Hanrahan C et al. Progression and regression of premalignant cervical lesion in HIV infected women from Soweto: a perceptive cohort. AIDS. 2011; 25 (1): 87-94. |
| [11] | Bassey G, Jeremiah I, Ikimalo JI, Fiebai PO, Athanasius BP. Abnormal cervical cytology among HIV-positive women in Nigeria. Int J Gynaecol Obstet 2014; 125(2): 103-6. |
| [12] | Howard M, Ye Z, Robert D, Joel M, Xiaonan X, Heather W et al. Influence of adherent and effective antiretroviral therapy use on HPV infection and squamous intraepithelial lesion in HIV positive women. J infect dis; 2010(5): 681-690. |
| [13] | Minkoff H, Massad LS, Anastos K, et al. The effect of highly active antiretroviral therapy on cervical cytology changes associated with oncogenic HPV among HIV-infected women. AIDS; 2001. 15: 2157–2164. |
| [14] | Heard UM, Schmitz V, Costagliola D, Orth G, Kazatchkline MD. Early Regression of Cervical Lesion in HIV-seropositive Women receiving highly active antiretroviral therapy. AIDS.1998; 12 (12): 1459–64. |
| [15] | Denslow SA, Rositch AF, Firnhaber C, Ting J, Smith JS. Incidence and progression of cervical lesions in women with HIV: a systematic global review. Int J STD AIDS 2014; 25(3): 163-77. |
| [16] | Sirera G, Videla S, Lopez-Blazquez R, et al. Evolution of cervical cytologic changes among HIV infected women with normal cytologic in the HAART era. AIDS Res Hum Retroviruses. 2007; 23(8): 965-71. |
| [17] | Del Mistro A, Bertorelle R, Franzetti M, Marzia F, Annamaria C, Angela T et al. Antiretroviral therapy and the clinical evolution of HPV –associated genital lesions in HIV –positive women. Clin Infect Dis. 2004; 38(5): 737-42. |
| [18] | Rabiu K, Akinbami A, Adewunmi A, Akinola O, Wright O The Need to Incorporate Routine Cervical Cancer Counseling and Screening in the Management of HIV Positive Women in Nigeria. Asian Pac J Cancer Prev. 2011; 12(5): 1211-4. |
| [19] | Araoye MO. Subject selection. In: Araoye MO (editor). Research Methodology with Statistics for Health and Social Sciences, Ilorin. Nathadex; 2003, 115-29. |
| [20] | Agada PA, Thacher TD, Ekwempu CC, Idoko JA. Cervical dysplasia in Nigerian women infected with HIV. Int J Gynecol Obstet 2009; 107(2): 99-102. |
| [21] | Adefuye PO. Knowledge and practice of cervical screening among professional health workers in a suburban district in Nigeria. Nigerian Medical Practitioner 2006; 50: 19-22. |
| [22] | Banura C, Franceschi S, Vandoom L, Arslan A, Wabwire MF, Mbidde E. Infection with HPV and HIV in young women in Kampala, Uganda. J infect dis. 2008; 197: 555-556. |
| [23] | Anorlu RI, Igwilo CI, Akanmu AS, Banjo AA, Odunukwe NN, Okany CC et al. Prevalence of abnormal cervical smear among patients with HIV in Lagos, Nigeria. West Afr J Med 2007; 26 (2): 143-7. |
| [24] | La Ruche G, Ramon R, Mensah-Ado I, Bergeron C, Diomande M, Sylla-Koko F et al. Squamous intraepithelial lesions of the cervix, invasive cervical carcinoma, and Immunosuppression induced by human immunodeficiency virus in Africa. Cancer. 1998; 15.82(12):2401. |
| [25] | Mbizvo EM, Msaya SE, Stray-Pedersen B, Chirenje MZ, Hussain A. Cervical dyskaryosis among women with or without HIV: prevalence and risk factors. Int J STD AIDS 2005; 16(2): 789-93. |
| [26] | Chama CM, Ngada H, Gashau W. Cervical dysplasia in HIV infected women in Maiduguri. Niger J Obstet Gynecol.2005; 25(3): 286-8. |
| [27] | Faduyile FA. The prevalence of cervical abnormalities in HIV positive women. National Postgraduate Medical College Dissertation in pathology 2005. |
