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Vol.1 , No. 4, Publication Date: Nov. 5, 2014, Page: 166-171
 apparently healthy students of African descent attending Usmanu Danfodiyo University in Sokoto North Western Nigeria aged 18-35 years and mean age 26 ± 2.0 years made up of 145 male (58.0%) and 105 female (42.0%) constituted the subjects in this present study. Haemoglobin electrophoresis pattern indicated that 176 (70.4%) were HbAA, 60 (24.0%) were HbAS, 2 (0.8%) were HbSS, and 12 (4.8%) were HbAC respectively. The prevalence of HbAS, HbSS and HbAC was higher among male students (13.6%, 0.8% and 2.8%) compared to female students (10.4%, 0% and 2%) respectively. Data derived from this study will help policy makers make evidenced –based decisions on pre-marital screening, genetic counseling, neonatal genetic testing for haemoglobinopathies, carrier screening, mutation identification screening and in the management of cases of disputed parentage. It can also help in the formulation of genetic counseling policies to help prospective couples make informed decisions in an effort to reduce the sickling gene pool in North Western Nigeria. We recommend that a sickle cell disease clinical care program that includes prophylaxis with penicillin to control infection, malarial prophylaxis; family training to identify early, severe, or persistent symptoms and increase awareness of the gravity of malarial crises, the evaluation of the patient’s nutritional status, fluid intake and education about the importance of regular medical visits should be implemented.&picture=http://www.aascit.org/aascit/decorators/img/journal/906.jpg)
| [1] | Onuigwe Festus Uche, Department of Haematology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [2] | Babangida Samuel, Department of Haematology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [3] | Erhabor Osaro, Department of Haematology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [4] | Abdulrahaman Yakubu, Department of Haematology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [5] | Isaac Zama, Department of Haematology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [6] | Adias Teddy Charles, Department of Haematology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [7] | Ezimah Anthony, Department of Haematology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [8] | Ibrahim Kwaifa, Department of Haematology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [9] | Buhari Hauwa, Department of Haematology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [10] | Okwesili Augustine, Department of Haematology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [11] | Ahmed Marafa, Department of Haematology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [12] | Yeldu Mainasara, Department of Haematology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [13] | Bachaka Sanusi Musa, Department of Haematology, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [14] | Yeldu Mohammed Haruna, Department of Clinical Biochemistry, Usmanu Danfodiyo University, Sokoto, Nigeria. |
| [15] | Dallatu Kabiru, Department of Clinical Biochemistry, Usmanu Danfodiyo University, Sokoto, Nigeria. |
Haemoglobinopathies are global public health problem and is predominant in the Mediterranean, African and Asian regions. This aim of this present study is to determine the distribution of some haemoglobin variants among students of African descent attending Usmanu Danfodiyo University in Sokoto North Western, Nigeria. Ethylenediamine tetracetic acid anticoagulated blood was used for the determination of haemoglobin electrophoresis. A total of two hundred and fifty (250) apparently healthy students of African descent attending Usmanu Danfodiyo University in Sokoto North Western Nigeria aged 18-35 years and mean age 26 ± 2.0 years made up of 145 male (58.0%) and 105 female (42.0%) constituted the subjects in this present study. Haemoglobin electrophoresis pattern indicated that 176 (70.4%) were HbAA, 60 (24.0%) were HbAS, 2 (0.8%) were HbSS, and 12 (4.8%) were HbAC respectively. The prevalence of HbAS, HbSS and HbAC was higher among male students (13.6%, 0.8% and 2.8%) compared to female students (10.4%, 0% and 2%) respectively. Data derived from this study will help policy makers make evidenced –based decisions on pre-marital screening, genetic counseling, neonatal genetic testing for haemoglobinopathies, carrier screening, mutation identification screening and in the management of cases of disputed parentage. It can also help in the formulation of genetic counseling policies to help prospective couples make informed decisions in an effort to reduce the sickling gene pool in North Western Nigeria. We recommend that a sickle cell disease clinical care program that includes prophylaxis with penicillin to control infection, malarial prophylaxis; family training to identify early, severe, or persistent symptoms and increase awareness of the gravity of malarial crises, the evaluation of the patient’s nutritional status, fluid intake and education about the importance of regular medical visits should be implemented.
Keywords
Haemoglobin Variants, Students, Usmanu Danfodiyo University, Sokoto, North Western Nigeria
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