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Vol.1 , No. 4, Publication Date: Nov. 2, 2014, Page: 161-165
 and Partial Thromboplastin Time with Kaolin (PTTK) in kidney failure patients. Fifty (50) clinically confirmed renal failure patients serving as the tests group and fifty age- matched non-renal failure subjects served as control for the study. During the study, 4.5ml of blood was collected from the subjects (tests and controls) into a bottle containing 0.5ml of trisodium Citrate and analysed for Prothrombin Time (PT) and Partial Thromboplastin Time with Kaolin (PTTK). The PT and PTTK were determined using manual method according to the manufacturer’s instructions. From the study, we observed that the mean PTTK and PT values of kidney failure patient and control groups were 33.7 ± 8.0 and 17.70 ± 3.9 seconds; and 36.3 ± 3.5 and 15.7 ± 1.6 respectively. The PTTK of tests subjects was lower and the PT was higher than that of controls (p < 0.05). The Mean ± standard deviation of PT of subjects males and females was compared with control males and females and found to be 16.3 ± 2.3 and 17.1 ± 3.8; 15.4 ± 1.1; and 16.0 ± 1.9 respectively. The PTTK was compared among subjects and control based on gender. The mean PTTK results were 35.0 ± 6.2 and 35.0 ± 6.4 for male and female subjects compared to 37.0 ± 3.9 and 35.8 ± 1.3 respectively for male and female controls. The difference however was not statistically significant (p> 0.05). We conclude that kidney failure leads to an increased in Prothrombin Time (PT) and decrease in Partial Thromboplastin Time with Kaolin (PTTK). These abnormalities in PT and PTTK could contribute to the bleeding diathesis found in patients with kidney failure. We advocate that renal failure patients should be placed on a balanced diet to keep their vitamin K intake consistent from day to day. And any changes in their diet or use of supplements should be made known to their healthcare provider. Regular monitoring of the coagulation profile of patients with renal failure is recommended.&picture=http://www.aascit.org/aascit/decorators/img/journal/906.jpg)
| [1] | Isaac Zama, Department of Haematology and Blood Transfusion Science, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto State, Nigeria. |
| [2] | Abdulrahaman Yakubu, Department of Haematology and Blood Transfusion Science, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto State, Nigeria. |
| [3] | Erhabor Osaro, Department of Haematology and Blood Transfusion Science, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto State, Nigeria. |
| [4] | Sadiya Usman, Department of Haematology and Blood Transfusion Science, Faculty of Medical Laboratory Science, Usmanu Danfodiyo University, Sokoto State, Nigeria. |
| [5] | Liman Hamidu Mohammed, Dialysis Center, Department of Medicine, Usmanu Danfodiyo University Teaching Hospital, Sokoto State, Nigeria. |
| [6] | Aghedo Festus, Department of Haematology and Blood Transfusion Science, Usmanu Danfodiyo University Teaching Hospital, Sokoto State, Nigeria. |
| [7] | Uko Emmanuel Kufre, Department of Haematology and Transfusion Science, University of Calabar, Cross Rivers State, Nigeria. |
Background: Renal failure or kidney failure is a condition in which the kidneys fail to adequately filter toxins and waste products from the blood. The World Health and Global Burden of Disease project reports show that kidney disease contribute to the global burden of diseases—with approximately 850,000 deaths every year and 15,010,167 disability-adjusted life styles. This study was carried out to estimate the Prothrombin Time (PT) and Partial Thromboplastin Time with Kaolin (PTTK) in kidney failure patients. Fifty (50) clinically confirmed renal failure patients serving as the tests group and fifty age- matched non-renal failure subjects served as control for the study. During the study, 4.5ml of blood was collected from the subjects (tests and controls) into a bottle containing 0.5ml of trisodium Citrate and analysed for Prothrombin Time (PT) and Partial Thromboplastin Time with Kaolin (PTTK). The PT and PTTK were determined using manual method according to the manufacturer’s instructions. From the study, we observed that the mean PTTK and PT values of kidney failure patient and control groups were 33.7 ± 8.0 and 17.70 ± 3.9 seconds; and 36.3 ± 3.5 and 15.7 ± 1.6 respectively. The PTTK of tests subjects was lower and the PT was higher than that of controls (p < 0.05). The Mean ± standard deviation of PT of subjects males and females was compared with control males and females and found to be 16.3 ± 2.3 and 17.1 ± 3.8; 15.4 ± 1.1; and 16.0 ± 1.9 respectively. The PTTK was compared among subjects and control based on gender. The mean PTTK results were 35.0 ± 6.2 and 35.0 ± 6.4 for male and female subjects compared to 37.0 ± 3.9 and 35.8 ± 1.3 respectively for male and female controls. The difference however was not statistically significant (p> 0.05). We conclude that kidney failure leads to an increased in Prothrombin Time (PT) and decrease in Partial Thromboplastin Time with Kaolin (PTTK). These abnormalities in PT and PTTK could contribute to the bleeding diathesis found in patients with kidney failure. We advocate that renal failure patients should be placed on a balanced diet to keep their vitamin K intake consistent from day to day. And any changes in their diet or use of supplements should be made known to their healthcare provider. Regular monitoring of the coagulation profile of patients with renal failure is recommended.
Keywords
Kidney Failure, Coagulation Profile, Sokoto, Nigeria
Reference
| [01] | Feest, T.G., Round, A., and Hamad, S. (1993). Incidence of severe acute renal failure in adults: results of a community based study. BMJ 306(6876): 481-483. |
| [02] | World Health Organization, “Global burden of disease,” March 2006,http://www3.who.int/whosis/menu.cfm?path=evidence. |
| [03] | Wen, C.P., Cheng, T.Y. Tsai, M.K., Chang, Y.C. Chan, H.T. and Tsai, S.P. (2008). All-cause mortality attributable to chronic kidney disease: a prospective cohort study based on 462 293 adults in Taiwan. Lancet 371(9631): 2173-2182. |
| [04] | Addo, J., Smeeth, L., and Leon, D.A. (2009). Hypertensive target organ damage in Ghanaian civil servants with hypertension. PloS One 4(8): 6672. |
| [05] | Bamgboye, E.L. (2006). End-stage renal disease in sub-Saharan Africa. Ethnicity & Disease 16(2 Suppl 2): S2-5-9. |
| [06] | Osafo, C. Mate-Kole, M. Affram, K. and Adu, D. (2011). Prevalence of chronic kidney disease in hypertensive patients in Ghana. Renal Failure 33(4): 388-392. |
| [07] | Jang, I.K. and Hursting, M.J. (2005). When heparins promote thrombosis: review of heparin-induced thrombocytopenia. Circulation 111(20): 2671-2683. |
| [08] | Rice, L. Nguyen, P.H. Vann, A.R. (2002). Preventing complications in heparin-induced thrombocytopenia. Alternative anticoagulants are improving patient outcomes. Postgraduate Medicine 112(3): 85-89. |
| [09] | Van, B. W. Vanholder, R. and Lameire, N. (2006). Defining acute renal failure: RIFLE and beyond. Clinical journal of the American Society of Nephrology : CJASN 1(6): 1314-1319. |
| [10] | Warkentin, T.E. (2004). Heparin-induced thrombocytopenia: diagnosis and management. Circulation 110(18): 454-458. |
| [11] | Khilji, S.A. and Khan, A.H. (2004). Acute renal failure after Cardiopulmonary Bypass Surgery. J Ayub Med Coll Abottabad 16: 25-28. |
| [12] | Nash, M.J., Cohen, H., Liesner, R.and Machin S.J. (2005). Acquired coagulation disorders and vascular bleeding. In: Hoffbrand HV, Catovsky D, Tuddenham EGD (Eds). Postgraduate Haematology, edn. Oxford UK: Blackwell publishing. Pp 859-875. |
| [13] | Ahmad, W., Ziaulllah, M.R., and Shafi, H.T. (2001). Acute renal failure; causes and outcome. Proceeding ShaikhZayed Postgrad Med Inst 15: 23-28. |
| [14] | Jamal, A. and Ramzan, A. (2004). Renal and post-renal causes of acute renal failure in children. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 14(7): 411-415. |
| [15] | http://sokotstategovernment.org .accessed October 19, 2012 |
| [16] | http://wikipedia.org/wiki/Sokoto_state accessed October 19, 2012 |
| [17] | Http://nigeria .UNFPA.org/sokoto.html accessed October 19, 2012 |
| [18] | http://www,africatiday.com accessed October 20, 2012 |
| [19] | Rafiq H., Zia R., Hamid A., Hameed A., Lone A., and Ashraf S. et al.,(2012). Study of Effects of Acute Renal Failure on Haemostasis. Special Edition Annals. 16(1): 248-251. |
| [20] | Alghythan A. K. and Alsaeed A. H. (2012). Hematological changes before and after hemodialysis. Scientific Research and Essays. 7(4), 490-497. |
| [21] | Misra D.P., Das S., Pattnaik M., Singh S.C., Jena R.K. (2011). Relationship of Hepatic and Renal Dysfunction with Haemorrheological Parameters in Plasmodium falciparum Malaria. Journals Association of Physicians of India. 59(2): 121-128. |
| [22] | Anand N.K., Chand G., Talib V.H., Chellani H., and Pande J. (1996). Hemostatic profile in nephritic syndrome. Indian pediatrician; 33(12): 1005-12. |
| [23] | Joshua L.H. and Charles S.E. (2008). Evaluation of a Prolonged Prothrombin Time: laboratory evaluation of prolonged results for screening coagulation tests. The American Association for Clinical Chemistry. 82(4): 864-873. |
| [24] | Sofo CA, Ali-Akpajiak, Pyke T. Social development and poverty in Nigeria. Increasing poverty in Nigeria. 2003. Oxfam Working Paper. |
| [25] | Ofoegbu EN. Cardiac Autonomic Neuropathy in Nigerian Type 2 Diabetes Mellitus Patients. Glob J Med Sci 2005; 4:52-58. |
| [26] | WHO 2004 Diabetes Action Now Booklet. Geneva, Switzerland: World Health Organization; 2004. Available from: http://www: who.int/diabetes/ booklet [Last accessed on 2008 Oct 31]. |
| [27] | NNR 2012 |
| [28] | Shearer MJ, Newman P. Metabolism and cell biology of vitamin K. Thromb Haemost 311 2008; 100: 530-547. |
| [29] | Suttie JW. Synthesis of vitamin K-dependent proteins. FASEB J 1993; 7: 445-452. |
| [30] | Gijsbers BLMG, Jie KSG, Vermeer C. Effect of food composition on vitamin K absorption in 243 human volunteers. Br J Nutr 1996; 76: 223-229. |
| [31] | Riesmann, D. (1957). Haemorrhages in course of Bright's disease with special reference to the occurrence of a haemorrhagic diathesis of nephritic origin. American Journal of Medical Science, 134: 709-716, 1907. |
| [32] | Larsson, S. O. Hedner, U. and Nilsson, I. M. (2000). On coagulation and fibrinolysis in conservatively treated chronic uraemia. Acta Medicine Scand., 189(1): 433-441. |
| [33] | Sanchez-Avalos, J. Vitacco, M. Molines, F. Penalver, J. and Giananntonio, C. (1997). Coagulation studies in haemolytic uraemic syndrome. Journal of Paediatrician. 76: 538-548. |
