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Vol.5 , No. 4, Publication Date: Jun. 1, 2018, Page: 58-63
-Clovamide Derivatives&description=A peptide coupling reaction between L-phenylalanine (L-DOPA) and cinnamic acids derivatives has been successfully employed for the synthesis of a set of small molecules derived from trans (-) clovamide. The antioxidant activity of these derivative molecules is reported. The antioxydant and antiradical activity were determined using DPPH (2-2-Diphenyl picrylhydrazyl) radical. The molecules which exhibit interesting antioxidant activity were: compound 5 (IC<sub>50</sub> =3.46±0.034µg/ml); compound 6 (IC<sub>50</sub> =3.04±0.01 µg/ml); compound 7 (IC<sub>50</sub> =4.23±0.02 µg/ml); compound 8 (IC<sub>50</sub> =5.1±0.061 µg/ml); compound 9 (IC<sub>50</sub> =1.55±0.17 µg/ml); compound 10 (IC<sub>50</sub> =6.02±0.07 µg/ml) and compound 13 (IC<sub>50</sub> =2.49±0.06 µg/ml). These molecules contain polyphenols wich are generally very good antioxidants. Thus, this study showed that compound 9 with an IC<sub>50</sub> of 1.55 µg/ml has antioxidant activity close to that of quercetin (IC<sub>50</sub> = 1.20µg/ml), a well known antioxidant compound.&picture=http://www.aascit.org/aascit/decorators/img/journal/905.jpg)
| [1] | Serigne Omar Sarr, Faculté de Médecine et de Pharmacie, Université Cheikh Anta DIOP, Dakar, Sénégal. |
| [2] | Abdoulaye Gassama, Faculté des Science et Technologies, Université Assane Seck, Ziguinchor, Sénégal. |
| [3] | Françoise Manga, Faculté de Médecine et de Pharmacie, Université Cheikh Anta DIOP, Dakar, Sénégal. |
| [4] | Fabienne Grellepois, Institut de Chimie Moléculaire de Reims, Université de Reims, Reims, France. |
| [5] | Catherine Lavaud, Institut de Chimie Moléculaire de Reims, Université de Reims, Reims, France. |
A peptide coupling reaction between L-phenylalanine (L-DOPA) and cinnamic acids derivatives has been successfully employed for the synthesis of a set of small molecules derived from trans (-) clovamide. The antioxidant activity of these derivative molecules is reported. The antioxydant and antiradical activity were determined using DPPH (2-2-Diphenyl picrylhydrazyl) radical. The molecules which exhibit interesting antioxidant activity were: compound 5 (IC50 =3.46±0.034µg/ml); compound 6 (IC50 =3.04±0.01 µg/ml); compound 7 (IC50 =4.23±0.02 µg/ml); compound 8 (IC50 =5.1±0.061 µg/ml); compound 9 (IC50 =1.55±0.17 µg/ml); compound 10 (IC50 =6.02±0.07 µg/ml) and compound 13 (IC50 =2.49±0.06 µg/ml). These molecules contain polyphenols wich are generally very good antioxidants. Thus, this study showed that compound 9 with an IC50 of 1.55 µg/ml has antioxidant activity close to that of quercetin (IC50 = 1.20µg/ml), a well known antioxidant compound.
Keywords
Antioxidant, Antiradical, trans-(-)-Clovamide, DPPH
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