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Vol.1 , No. 3, Publication Date: Sep. 3, 2014, Page: 84-89
 on the Histology of the Liver Using Adult Male Rats&description=The use of botanical medicine is ancient and plant chemicals are still the backbone of our pharmacopoeia because more than 50% of drugs used in Western pharmacopoeia are isolated from herbs or derived from modification of chemicals first found in plants. Zingiber officinale is one of the most widely used herbs and food flavouring agent and commonly known as ginger. This study was done to evaluate the possible histological effect(s) of ethanolic extract of Zingiber offinale on the liver of adult male albino rats. Twenty five (25) adult wistar rats weighing between 125-200g were divided into five groups of five (5) rats each. Group C, D and E served as experimental groups while group A and B served as the control groups. Group C was administered a dose of 100mg/kg of the extract, group D was given oral dose of 250mg/kg of the extract while group E was given oral dose of 500mg/kg of Zingiber officinale extract. Administration of extract lasted for fourteen days at the end of which the animals were sacrificed using chloroform-inhalation method. The liver was harvested as tissue samples from sacrificed animals for pathological examination using routine histological procedure and stained with the haematoxylin and eosin stains. Histological examinations of liver showed that after treatment with low and medium doses (100, 250mg/kg) the ginger extract produced little damaging effects on the liver histology, but at higher doses (500mg/kg) the liver shows marked dilatation of the central vein and sinusoidal spaces as well as loss of cytoplasmic material. Therefore, Zingerber officinale should be used with caution because it may have deleterious effects on the liver cells at high doses.&picture=http://www.aascit.org/aascit/decorators/img/journal/903.jpg)
| [1] | Kebe, E. Obeten, Department of Anatomy, University of Calabar, Calabar, Nigeria. |
| [2] | Patricia P. Obasee, Department of Anatomy, University of Calabar, Calabar, Nigeria. |
| [3] | Victoria N. Isaac, Department of Anatomy, University of Calabar, Calabar, Nigeria. |
| [4] | Amabe O. Akpantah, Department of Anatomy, University of Calabar, Calabar, Nigeria. |
The use of botanical medicine is ancient and plant chemicals are still the backbone of our pharmacopoeia because more than 50% of drugs used in Western pharmacopoeia are isolated from herbs or derived from modification of chemicals first found in plants. Zingiber officinale is one of the most widely used herbs and food flavouring agent and commonly known as ginger. This study was done to evaluate the possible histological effect(s) of ethanolic extract of Zingiber offinale on the liver of adult male albino rats. Twenty five (25) adult wistar rats weighing between 125-200g were divided into five groups of five (5) rats each. Group C, D and E served as experimental groups while group A and B served as the control groups. Group C was administered a dose of 100mg/kg of the extract, group D was given oral dose of 250mg/kg of the extract while group E was given oral dose of 500mg/kg of Zingiber officinale extract. Administration of extract lasted for fourteen days at the end of which the animals were sacrificed using chloroform-inhalation method. The liver was harvested as tissue samples from sacrificed animals for pathological examination using routine histological procedure and stained with the haematoxylin and eosin stains. Histological examinations of liver showed that after treatment with low and medium doses (100, 250mg/kg) the ginger extract produced little damaging effects on the liver histology, but at higher doses (500mg/kg) the liver shows marked dilatation of the central vein and sinusoidal spaces as well as loss of cytoplasmic material. Therefore, Zingerber officinale should be used with caution because it may have deleterious effects on the liver cells at high doses.
Keywords
Ginger, Histology, Ethanolic Extract, Liver, Wistar Rat
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