ISSN: 2375-3811
International Journal of Biological Sciences and Applications  
Manuscript Information
 
 
A Study of Facilitated Oxygen Diffusion in Humans in ALBAHA (KSA)
International Journal of Biological Sciences and Applications
Vol.3 , No. 2, Publication Date: Mar. 3, 2016, Page: 29-37
2517 Views Since March 3, 2016, 1062 Downloads Since Mar. 3, 2016
 
 
Authors
 
[1]    

A. H. Ansari, Department of Mathematics, Albaha University, Albaha, KSA.

 
Abstract
 

The paper analyses the facilitated oxygen diffusion in skeletal muscle fibre in steady and extinction states at province AlBAHA of Kingdom of Saudi Arabia. The oxygen being continuously consumed by human body, diffuses in muscle fibre as well as binds with the myoglobin to produce oxy-myoglobin. With the increase of high altitude, oxygen concentration decreases exponentially and consequently, it results oxygen debt causing various illnesses. The altitude of ALBAHA varies from 1600 to 2500 meters above sea level. In case of insufficient oxygen supply at high altitude, oxy-myoglobin releases oxygen to meet the requirement in the human body to some extent. Subsequently, the point of zero oxygen concentration (anoxia) recedes towards the exterior surface of the human body (a worsen situation). The movement of point of anoxia depends upon the rate of absorption of oxygen by the human body and height from the sea level. An appropriate numerical method has been used to find the oxygen concentration at any time at any point in the human body as a function of rate of oxygen consumption and the facilitated diffusion parameter at different altitude at ALBAHA. The obtained results are compared with the results available in literature, which are in close agreement.


Keywords
 

Facilitated, Oxygen Diffusion, Humans, Altitude, ALBAHA


Reference
 
[01]    

http://www.al-baha.net/.

[02]    

Al Tahan A1, Buchur J, el Khwsky F, Ogunniyi A, al-Rajeh S, Larbi E, Daif A, Bamgboye E.“Risk factors of stroke at high and low altitude areas in Saudi Arabia”, Arch Med Res. 1998 Summer; 29(2):173-7.

[03]    

Young, Andrew J; Reeves, John T. (2002). “Human Adaptation to High Terrestrial Altitude”, Medical Aspects of Harsh Environments, Borden Institute, Washington, DC. Retrieved 2009-01-05.

[04]    

Muza, SR; Fulco, CS; Cymerman, A (2004). “Altitude Acclimatization Guide”, US Army Research Inst. of Environmental Medicine Thermal and Mountain Medicine Division Technical Report (USARIEM–TN–04–05). Retrieved 2009-03-05.

[05]    

Moore, LG; Niermeyer, S; Zamudio, S.“Human adaptation to high altitude: Regional and life-cycle perspectives”, Am. J. Phys. Anthropol, 1998,107: 25–64.

[06]    

Moore, Lorna G. “Human Genetic Adaptation to High Altitude”, High Altitude Medicine & Biology, June 2001, 2 (2): 257–279

[07]    

Fayed, N; Modrego, P.J.; Morales, H, “Evidence of brain damage after high-altitude climbing by means of magnetic resonance imaging”, The American Journal of Medicine (Elsevier), 2006, 119 (2): 168.

[08]    

Huey, Raymond B.; Eguskitza, Xavier.” Limits to human performance: elevated risks on high mountains”, J. Experimental Biology, July 2001, 204 (18): 3115–9.

[09]    

Stray-Gundersen, J; Chapman, RF; Levine, BD, “Living high-training low" altitude training improves sea level performance in male and female elite runners”, Journal of Applied Physiology, September 2001,91 (3): 1113–20.

[10]    

Crank, J. and Gupta, R. S., “A moving boundary problem arising from the diffusion of oxygen in absorbing tissue”, J. Inst. Math. Appl., 1972, 10, 19–33.

[11]    

Marquina, A. and Martinez, V., “Shooting methods for onedimensional steady-state free boundary problems”, Comput. Math. Appl., 1993, 25, 39–46.

[12]    

Martinez, V., Marquina, A. and Donat, R., “Shooting methods for one-dimensional diffusion–absorption problems”, SIAM J. Numer. Anal., 1994, 572–589.

[13]    

Huxley, A. F., “Muscle structure and theories of contraction”, Prog. Biophys. 1957, 7, 255–318.

[14]    

Hodgkin, A. L., “Chance and design in electrophysics: An informal account of certain experiments on nerve carried out between 1934and 1952”, J. Phys., 1976, 263, 1–21.

[15]    

Eric P. Salathe and Robert W. Kolkka, “Reduction of anoxia through myoglobin – facilitated diffusion of oxygen”, Bio Physics Jl., vol-50,1986,885-894.

[16]    

Ansari, A. H., “Facilitated oxygen diffusion in muscle fibre”, Journal of Current Science 95(6), 751-759, 2008

[17]    

Murray J.D., “On the molecular mechanism of facilitated oxygen diffusion by haemoglobin and myoglobin”, Proc R Soc Lond B Biol Sci. 1971 Jun 15; 178(50):95–110

[18]    

Keener, J. and Sneyd, J., Interdisciplinary applied mathematics. In Mathematical Physiology 8, Springer, New York, 1998

[19]    

Dufour, SP; Ponsot, E.; Zoll, J.; Doutreleau, S.; Lonsdorfer-Wolf, E.; Geny, B.; Lampert, E.; Flück, M.; Hoppeler, H.; Billat, V.; Mettauer, B.; Richard, R.; Lonsdorfer, J. (April 2006).” Exercise training in normobaric hypoxia in endurance runners. I. Improvement in aerobic performance capacity”, Journal of Applied Physiology100 (4): 1238–48. Retrieved 2009-01-05.

[20]    

Levine, BD; Stray-Gundersen, J (November 2005). “Point: positive effects of intermittent hypoxia (live high:train low) on exercise performance are mediated primarily by augmented red cell volume, “Journal of Applied Physiology99 (5): 2053–5. Retrieved 2009-01-05.

[21]    

Gore, CJ; Hopkins, WG (November 2005).” Counterpoint: positive effects of intermittent hypoxia (live high:train low) on exercise performance are not mediated primarily by augmented red cell volume”, Journal of Applied Physiology99 (5): 2055–7; discussion 2057–8. Retrieved 2009-01-05.

[22]    

Douglas; Jim Jr and Gallie; Jr, T. M., On the numerical integration of a parabolic differential equation subject to a moving boundary condition. Duke Math. J., 1955, 4, 557–571.

[23]    

Murray, W. D. and Landis, F., J. Heat Transfer 81, (1959), pp 106-112.

[24]    

Ehrlich, L. W., “A numerical method of solving a heat flow problem with moving boundary”, J. ACM, 1958, 5, 161–176.

[25]    

Lotkin, M.; Q. appl. Math. 18, (1960), pp 79-85.

[26]    

Crank, J., “Two methods for the numerical solution in diffusion and heat flow”, Q. J. Mech. Appl. Math., 1957, 10, 220–231.

[27]    

Hansen, E. and Hougaard, P., “On a moving boundary problem”, J. Inst. Math. Appl., 1974, 13, pp 385-398.

[28]    

Rogers; J. C. W.,“A free boundary problem as diffusion with nonlinear absorptions”, J. Inst. Math. Appl., 1977, 20, pp 264-268.

[29]    

A. Roberto Frisancho, “Developmental functional adaptation to high altitude: review”, American Jl of human biology, 2013, 25(2),151-168.

[30]    

Bianda, Sveinling, Berntsen, Lars Bo Anderson, Hein Stigum, Ouzhuluobo per Nafstad Tianyi Wu Espen Bjertness, “Exercise capacity selected physiological factors by ancestry and residential altitude: cross section studies of 9-10 years old childrens in Tibet”, jl. High altitude Medice and Biology, 2014, 15(2), 162-169.

[31]    

U. Barkai, G C Wier C K Colton B Lodwing, “Enhanced oxygen supply improves the viability in new bio artificial pancreas”, Jl. Cell transplantation, 2013, Vol 22(8), 1463-1476.

[32]    

J S Hunch, R J Theilmann, Z M Smith, M Scanding, “Cerebral diffusion and T2: MRI predictors of acute mountain sickness during sustained high altitude hypoxia”, Jl. Of cerebral blood flow and metabolism 2013, 33, 372-380.





 
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