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International Journal of Biological Sciences and Applications

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Detection of Early Stage Renal Disease by Elevation of Certain Low Molecular Weight Proteins in Urine of Diabetes Patients

International Journal of Biological Sciences and Applications
Vol.1 , No. 1, Publication Date: Jul. 7, 2014, Page: 15-18

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Authors

[1]	Nazarian Zahra , International branch sahhid beheshti Medical Science Un. Tehran, Iran.
[2]	Mohiti Ardekani Javad , Clinical Biochemistry. Dept. Yazd Medical Science Un. Yazd, Iran.
[3]	Nazarian Aboalfazl , Clinical Biochemistry. Dept. Zanjan Medical Science Un. Zanjan, Iran.

Abstract

Background: Early detection of kidney failure is critical since it is the first message for the advanced process of nephropathy. Objectives: this study is stated the correlation between glycemic control and urinary certain low molecular weight proteins (LMWP); retinol binding protein (RBP) and nerve growth factor receptor (NGFR). Methods: 30 patients with diabetes mellitus type 2 between age of 30-70 with a normal serum creatinine (<1.3mg/dl) and 30 healthy individuals in same age and sex group were randomly selected. Results: There was significant increase in RBP (P< 0.001), NGFR (P<0.005) and HbA1c (glycosylated hemoglobin) (P<0.001) in diabetics patients as compared to control group, and obtained significant correlation between LMWP and HbA1c. This study was showed negative correlation between conventional markers for subclinical nephropathy like: serum and urine creatinine, urine albumin, creatinine clearance and 24h urine protein with LMWP. Conclusion: certain tubular LMWP may alert as early stage biomarkers for predicting of renal dysfunction.

Keywords

Diabetic Nephropathy, Low Molecular Proteins, Retinol Binding Protein, Nerve Growth Factor Receptor

Reference

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