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Vol.2 , No. 5, Publication Date: Jul. 21, 2015, Page: 42-47
 of experimental rats for fourteen days. A total of 24 matured female rats were completely randomized into six groups of 4 each. The six groups received normal food and water. Additionally, Groups 1-5 received 1000, 2000, 3000, 4000 and 5000 mg kg-1 body weight of the extract respectively twice daily. The female rats were sacrificed after two weeks of the experiment. Samples were collected from each rat by cardiac puncture using sterile syringes. Administration of the extract produced significant increase (p<0.05) in the serum prolactin, follicle-stimulating hormone and luteinizing hormone concentration whereas those of estradiol, progesterone were significantly reduced. Photomicrographs of rats from the Control Group showed normal architecture of ovarian cells. While rats in Group 1 showed partially destroyed ovarian cells, rats from Groups 2-5 showed completely destroyed ovarian cells. The result showed that the aqueous extract had a significant effect on both the reproductive hormones and the ovary but not on the uterus.&picture=http://www.aascit.org/aascit/decorators/img/journal/903.jpg)
| [1] | Onyegeme-Okerenta B. M., Department of Biochemistry, Faculty of Biological and Chemical Sciences, College of Natural and Applied Sciences, University of Port Harcourt, Choba, Rivers State, Nigeria. |
| [2] | Essien E. B., Department of Biochemistry, Faculty of Biological and Chemical Sciences, College of Natural and Applied Sciences, University of Port Harcourt, Choba, Rivers State, Nigeria. |
This study assessed the effects of aqueous leaf extract of Millettia aboensis on the female reproductive hormones and organs (ovary and uterus) of experimental rats for fourteen days. A total of 24 matured female rats were completely randomized into six groups of 4 each. The six groups received normal food and water. Additionally, Groups 1-5 received 1000, 2000, 3000, 4000 and 5000 mg kg-1 body weight of the extract respectively twice daily. The female rats were sacrificed after two weeks of the experiment. Samples were collected from each rat by cardiac puncture using sterile syringes. Administration of the extract produced significant increase (p<0.05) in the serum prolactin, follicle-stimulating hormone and luteinizing hormone concentration whereas those of estradiol, progesterone were significantly reduced. Photomicrographs of rats from the Control Group showed normal architecture of ovarian cells. While rats in Group 1 showed partially destroyed ovarian cells, rats from Groups 2-5 showed completely destroyed ovarian cells. The result showed that the aqueous extract had a significant effect on both the reproductive hormones and the ovary but not on the uterus.
Keywords
Millettia aboensis, Female Reproductive Hormones, Ovary, Uterus, Photomicrograph
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