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Vol.2 , No. 1, Publication Date: Nov. 28, 2014, Page: 18-21
 Carriage Amongst Tertiary School Students&description=Methicillin resistant Staphylococcus aureus (MRSA) started making wave soon after the introduction of methicillin (a more potent drug than penicillin) into clinical medicine in the early 1960’s. Methicillin, a beta-lactam drug was introduced for clinical use following the resistance of pathogenic bacteria to penicillin. Though implicated in some nosocomial infections, strains of S. aureus that are multidrug resistant known as community-acquired MRSA (ca-MRSA) now occur in the community and these are now widespread especially in places where antibiotics are used for other non-clinical purposes such as in livestock production and animal husbandry. This study evaluated the occurrence of ca-MRSA amongst tertiary school students in Ebonyi State, southeast of Nigeria. Swab stick specimens were aseptically collected from the nares, ears and skin of 20 consenting students, and these were analyzed based on standard bacteriological techniques. Antimicrobial susceptibility studies was carried out in line with the CLSI guideline using the Kirby-Bauer disk diffusion method and ca-MRSA isolates was phenotypically confirmed using a double disk diffusion technique based on detecting reduced susceptibility to oxacillin (1 µg) disk. Antimicrobial susceptibility test result showed that the pathogenic S. aureus isolated in this study showed reduced susceptibility to ceftazidime (100 %), cefoxitin (100 %), cefuroxime (80 %), ampicillin (33.3 %) and oxacillin (75 %). However, they were susceptible to erythromycin and clindamycin. The carriage rate of ca-MRSA in this study was 75 %. The expansion of ca-MRSA strains in the community poses public health issues due to their multidrug resistant profile. Proper monitoring of ca-MRSA strains in both the community and hospital environment is critical to forestalling any disease outbreak due to them. And this should be followed with antibiotic stewardship in both the community and hospital environment to preserve the efficacy of available drugs.&picture=http://www.aascit.org/aascit/decorators/img/journal/902.jpg)
| [1] | Iroha Ifeanyichukwu, Department of Applied Microbiology, Ebonyi State University, P. M. B 053, Abakaliki, Nigeria. |
| [2] | Ejikeugwu Chika, Department of Pharmaceutical Microbiology and Biotechnology, Nnamdi Azikiwe University, P. M. B 5025, Awka, Nigeria. |
| [3] | Nwakaeze Emmanuel, Department of Applied Microbiology, Ebonyi State University, P. M. B 053, Abakaliki, Nigeria. |
| [4] | Oji Anthonia, Department of Applied Microbiology, Ebonyi State University, P. M. B 053, Abakaliki, Nigeria. |
| [5] | Afiukwa Ngozi, Department of Applied Microbiology, Ebonyi State University, P. M. B 053, Abakaliki, Nigeria. |
| [6] | Udu-Ibiam Esther, Department of Applied Microbiology, Ebonyi State University, P. M. B 053, Abakaliki, Nigeria. |
Methicillin resistant Staphylococcus aureus (MRSA) started making wave soon after the introduction of methicillin (a more potent drug than penicillin) into clinical medicine in the early 1960’s. Methicillin, a beta-lactam drug was introduced for clinical use following the resistance of pathogenic bacteria to penicillin. Though implicated in some nosocomial infections, strains of S. aureus that are multidrug resistant known as community-acquired MRSA (ca-MRSA) now occur in the community and these are now widespread especially in places where antibiotics are used for other non-clinical purposes such as in livestock production and animal husbandry. This study evaluated the occurrence of ca-MRSA amongst tertiary school students in Ebonyi State, southeast of Nigeria. Swab stick specimens were aseptically collected from the nares, ears and skin of 20 consenting students, and these were analyzed based on standard bacteriological techniques. Antimicrobial susceptibility studies was carried out in line with the CLSI guideline using the Kirby-Bauer disk diffusion method and ca-MRSA isolates was phenotypically confirmed using a double disk diffusion technique based on detecting reduced susceptibility to oxacillin (1 µg) disk. Antimicrobial susceptibility test result showed that the pathogenic S. aureus isolated in this study showed reduced susceptibility to ceftazidime (100 %), cefoxitin (100 %), cefuroxime (80 %), ampicillin (33.3 %) and oxacillin (75 %). However, they were susceptible to erythromycin and clindamycin. The carriage rate of ca-MRSA in this study was 75 %. The expansion of ca-MRSA strains in the community poses public health issues due to their multidrug resistant profile. Proper monitoring of ca-MRSA strains in both the community and hospital environment is critical to forestalling any disease outbreak due to them. And this should be followed with antibiotic stewardship in both the community and hospital environment to preserve the efficacy of available drugs.
Keywords
Antimicrobial Susceptibility, Pathogenic Staphylococci, Ca-MRSA, Nigeria
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