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Vol.2 , No. 1, Publication Date: Jul. 9, 2016, Page: 1-7
 Starch in Sulphadimidine Suspension&description=Starch is a natural polysaccharide polymeric material occurring in the leaves, seeds, stems, tubers and roots of plants. It is one of the most commonly used excipients in pharmaceutical formulations because of its low-cost, relative abundance and inertness. <i>Cyperus esculentus</i> is a perennial herb of both the tropics and temperate regions of the world and is widely cultivated in Nigeria especially in the northern part. Until recently, its use had been limited to food and cosmetic applications. This research is aimed at ascertaining the suitability of <i>C. esculentus</i> starch as a suspending agent in sulphadimidine suspension and to compare its suspending properties with that of compound tragacanth BP (reference). Starch was isolated from <i>C. esculentus</i> tubers and suspensions of sulphadimidine containing <i>C. esculentus</i> starch prepared according to the British Pharmacopoeia formula were compared to those containing compound tragacanth BP at a concentration range of 2%, 4%, 6% and 8% <sup>w</sup>/<sub>v</sub>. The sedimentation profile (volume and height), redispersibility, flocculation studies and rheological behaviour of the suspensions were used as evaluation parameters. The results obtained showed that suspensions prepared with <i>C. esculentus</i> starch had superior suspending properties to those formulated with compound tragacanth BP (P<0.05) at all concentrations studied. This study therefore indicates that <i>C. esculentus</i> starch is suitable for use as a suspending agent in pharmaceutical suspensions due to its inherent characteristics.&picture=http://www.aascit.org/aascit/decorators/img/journal/893.jpg)
| [1] | Okorie O., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Rivers State, Nigeria. |
| [2] | Azaka J. E., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Rivers State, Nigeria. |
| [3] | Ibeshi E., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Rivers State, Nigeria. |
Starch is a natural polysaccharide polymeric material occurring in the leaves, seeds, stems, tubers and roots of plants. It is one of the most commonly used excipients in pharmaceutical formulations because of its low-cost, relative abundance and inertness. Cyperus esculentus is a perennial herb of both the tropics and temperate regions of the world and is widely cultivated in Nigeria especially in the northern part. Until recently, its use had been limited to food and cosmetic applications. This research is aimed at ascertaining the suitability of C. esculentus starch as a suspending agent in sulphadimidine suspension and to compare its suspending properties with that of compound tragacanth BP (reference). Starch was isolated from C. esculentus tubers and suspensions of sulphadimidine containing C. esculentus starch prepared according to the British Pharmacopoeia formula were compared to those containing compound tragacanth BP at a concentration range of 2%, 4%, 6% and 8% w/v. The sedimentation profile (volume and height), redispersibility, flocculation studies and rheological behaviour of the suspensions were used as evaluation parameters. The results obtained showed that suspensions prepared with C. esculentus starch had superior suspending properties to those formulated with compound tragacanth BP (P<0.05) at all concentrations studied. This study therefore indicates that C. esculentus starch is suitable for use as a suspending agent in pharmaceutical suspensions due to its inherent characteristics.
Keywords
Cyperus esculentus (Tiger Nut), Compound Tragacanth BP, Sulphadimidine Suspension, Suspending Properties, Natural Polysaccharide
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