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Vol.1 , No. 4, Publication Date: Aug. 31, 2015, Page: 45-50
 as a Novel Directly Compressible Filler-Binder-Superdisintegrant in Ibuprofen Tablet Formulation&description=Ibuprofen has poor water solubility. Its direct compressibility into tablet is difficult due to poor flowability and compactibility. The suitability of a novel multicomponent <i>Lentinus tuber regium</i> based co-processed excipient (<i>fizlent</i>) as a directly compressible (DC) filler-binder and superdisintegrant in ibuprofen tablet was investigated. Ibuprofen (76.92% w/w) blended with <i>fizlent </i> (22.58 % w/w) and lubricated with 0.50 % w/w magnesium stearate was compressed at 8 tons in Erweka table top single punch tablet press fitted with 8.50 mm biconvex punch and die. Tablet weights, total drug content, crushing strength, friability and disintegration time were determined using the British Pharmacopoeia methods. The basket method in Erweka dissolution apparatus at 50 rpm was used for dissolution study in 900 ml phosphate buffer (pH 7.2) at 37 ± 1<sup>o</sup> C for 60 min. The absorbance of samples withdrawn at 5 min intervals were spectrophometrically determined at wavelength of 221nm. Glossy, intact, off-white, round and convex shaped tablets obtained disintegrated within 30.17 ± 1.94s. Other tablet properties complied within pharmacopoeia limit. The application of <i>fizlent</i> as filler-binder in DC of ibuprofen tablet solved problem of its poor compactability and flowability. The ability of the tablet to break down completely in 30.17 ± 1.94 s shows that <i>fizlent</i> has a superdisintegrant property. This aided the early release and dissolution of ibuprofen, hence its ability to achieve T<sub>50</sub>, T<sub>80</sub> in less than 5 min and T<sub>90</sub> in 12.50 min. Furthermore, the onset of action and attainment of peak plasma concentration of ibuprofen will not be prolonged, thus, resolving the issues with poor water solubility noted for ibuprofen.&picture=http://www.aascit.org/aascit/decorators/img/journal/893.jpg)
| [1] | Ugoeze K. C., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Nigeria. |
| [2] | Nkoro V. O., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Nigeria. |
| [3] | Nwachukwu N., Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Nigeria. |
Ibuprofen has poor water solubility. Its direct compressibility into tablet is difficult due to poor flowability and compactibility. The suitability of a novel multicomponent Lentinus tuber regium based co-processed excipient (fizlent) as a directly compressible (DC) filler-binder and superdisintegrant in ibuprofen tablet was investigated. Ibuprofen (76.92% w/w) blended with fizlent (22.58 % w/w) and lubricated with 0.50 % w/w magnesium stearate was compressed at 8 tons in Erweka table top single punch tablet press fitted with 8.50 mm biconvex punch and die. Tablet weights, total drug content, crushing strength, friability and disintegration time were determined using the British Pharmacopoeia methods. The basket method in Erweka dissolution apparatus at 50 rpm was used for dissolution study in 900 ml phosphate buffer (pH 7.2) at 37 ± 1o C for 60 min. The absorbance of samples withdrawn at 5 min intervals were spectrophometrically determined at wavelength of 221nm. Glossy, intact, off-white, round and convex shaped tablets obtained disintegrated within 30.17 ± 1.94s. Other tablet properties complied within pharmacopoeia limit. The application of fizlent as filler-binder in DC of ibuprofen tablet solved problem of its poor compactability and flowability. The ability of the tablet to break down completely in 30.17 ± 1.94 s shows that fizlent has a superdisintegrant property. This aided the early release and dissolution of ibuprofen, hence its ability to achieve T50, T80 in less than 5 min and T90 in 12.50 min. Furthermore, the onset of action and attainment of peak plasma concentration of ibuprofen will not be prolonged, thus, resolving the issues with poor water solubility noted for ibuprofen.
Keywords
Lentinus tuber regium, Co-processed, fizlent, Directly Compressible, Filler-Binder-Superdisintegrant, Ibuprofen
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