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ISSN Print: 2381-103X ISSN Online: 2381-1048

American Journal of Biomedical Science and Engineering

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Synthesis, Characterization and Study of in vitro and in silico Anticancer Activity of (e)-2-Arylidene-1-Indanones

American Journal of Biomedical Science and Engineering
Vol.1 , No. 3, Publication Date: May 19, 2015, Page: 32-38

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Authors

[1]	Radhakrishnan Suresha, Department of Chemistry, Presidency College, Chennai, India.
[2]	Charles C. Kanakam, Department of Chemistry, Presidency College, Chennai, India.
[3]	Kesavan Dineshkumar, Department of Bioinformatics, School of Bioengineering, SRM University, Chennai, India.
[4]	Waheeta Hopper, Department of Bioinformatics, School of Bioengineering, SRM University, Chennai, India.

Abstract

Novel substituted (E)-2-benzylidene-1-indanones have been synthesized and evaluated for their cyto toxicity. 2-arylidene-4,7-diethylindan-1-one inhibited significantly the growth of MFC-7 cells in a dose dependent manner, without producing any alteration to the HBL-100 cells. Molecular docking studies were carried for all the synthesized compounds against estrogen receptor-alpha. Both in vitro and in silico studies suggest anticancer activity of (1-5) certain substituted (E)-2-benzylidene-1-indanones.

Keywords

(E)-2-Aryliden-1-Indanones, Antitumor Activity, Trifluoroacetic Anhydride, Molecular Docking

Reference

[01]	Tewari SC, Rastogi SN, Anand N. Studies in Antifertility Agents: Part IXXV 2-carboxy-7-hydroxy-1-phenyl-1, 2, 3, 4-tetrahydro fluorine. Indian J. Chem 1980; 198: 139.
[02]	Abdel-Gawad II, Kaddah AM, Khalil AM, Habib OMO, Al-Rifai H. Synthesis, biological activities of some new peptide substituted carbazoloquinones. Indian J. Chem 1982; 21B: 348-351.
[03]	Turk CF. Chem. Abstr 1976;84: 74461.
[04]	Coombs RV ,Houlihan WJ. Substituted naphtho pyrazoles. U.S. Patent 1976: 3,959,308.
[05]	Leval A, Patonay T. Reaction of E-2-Arylidene-1-indanones, Z-Aurones, Z-1¬Thioaurones and Z-2-Arylidene-2,3-dihydro-1H-indol-3-ones with Diazomethane. J. Heterocyl. Chem 1999; 36: 747.
[06]	Abe A, Radin NS, Shayman JA, Wotring LL, Zipkin RE, Sivakumar R, Ruggieri JM, Carson KG, Ganem B. Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth. B. J. Lipid Res 1995; 36(3): 611–621.
[07]	Dimmock JR., Kandepu NM, Nazarali AJ, Kowalchuk TP, Motaganahalli N, Quail JW, Mykytiuk PA, Audette G.F, Prasad L, Perjési P. Conformational and quantitative structure-activity relationship study of cytotoxic 2¬arylidenebenzocycloalkanones. J. Med. Chem 1999; 42(8): 1358-66.
[08]	Hsiencheng S, Lynn D, Carlos J, Carrera SA, Howard BC, Dennis, AC .Rational Design, Synthesis and Structure Activity Relationships of Antitumor (E)-2¬Benzylidene-1-tetralones and (E)-2-Benzylidene-1-indanones. Bio. Org. Med. Chem. Lett 2000; 10: 487.
[09]	Pena Ruiz J,Fernandez-Gomez M, Lopez Gonzalez J.J,Koziol AE, Grandino Roldan, M. Hydrogen bonds in 1-indanone: Charge density analysis and simulation of the inelastic neutron scattering spectrum in solid phase. J. Mol. Str 2005; 317(2): 159–170.
[10]	Hassner A, Cromwell NH, the Chemistry of Derivatives of 2-Benzaltetralone. II. Absorption Spectra and Stereostructure. J. Am. Chem. Soc 1958; 80: 893–900.
[11]	Neilson AJ, HaulinbanW. J. Org. React.16, 1-1440
[12]	Basavaiah D,Mallikarjuna Reddy R,Tet. Let. 2001; 42: 3025.
[13]	Thomas Klein,Roif M,Nusing Irngard Walsenburg-Boettcher Volker Ulrich. Biochem. Pharm. 1996; 51:285.
[14]	Basavaiah D, Mallikarjuna Reddy R. Indian J. Chem, 2001; 40B:985.
[15]	Lee,HJ, Kim TH, Kim JN. Bull. Korean Chem ; 22:1063.
[16]	Bayer,H, Batzl,C, HartmannR.W, Mannschreck A. J.Med.Chem 1991; 34:2685.
[17]	Basavaiah,D, Sarms,PKS. J.Chem. Soc. Chem. Commun 1992; 955.
[18]	Basavaiah D, Sarma,PKS, Bhavani,AKD.J. Chem, Soc. Chem. Commun 1994; 1091.