World Journal of Biochemistry and Molecular Biology  
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Kinetics and Mechanism of Electron-Transfer Reactions: Oxidation of Nalidixic Acid by Diperiodatocuprate (III) in Alkaline Medium
World Journal of Biochemistry and Molecular Biology
Vol.3 , No. 2, Publication Date: May 16, 2018, Page: 37-45
3721 Views Since May 16, 2018, 855 Downloads Since May 16, 2018

Gajala Tazwar, Department of Chemistry, Janki Devi Bajaj Government Girls College, Kota, India.


Mahima Sharma, Department of Chemistry, Janki Devi Bajaj Government Girls College, Kota, India.


Vijay Devra, Department of Chemistry, Janki Devi Bajaj Government Girls College, Kota, India.


The kinetics and mechanism of oxidation of nalidixic acid by diperiodatocuprate (III) in aqueous alkaline medium has been studied spectrophotometrically at 303 K. The reaction exhibits first order with respect to oxidant but substrate dependence is complex. The stoichiometry of the reaction has been observed to two moles of the oxidant for a mole of the substrate. The oxidation product of the substrate is 1-ethyl-2-hydroxy-1, 4-dihydro-7-methyl-4-oxo-1, 8-naphthyridine-3-carboxylic acid as established spectrally. The active species of diperiodatocuprate (III) is understood to be as monoperiodatocuprate (III). The activation parameters were also determined and discussed. The activation parameters and thermodynamics quantities were also determined and discussed. A plausible reaction mechanism has been suggested to account for experimental observations.


Diperiodatocuprate (III), Nalidixic Acid, Oxidation, Kinetics, Mechanism


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