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Reducing Power Antioxidant Activity and Effect of Time-Dose Dependent Administration of Allium sativum Oil Extract on Lipid Profile of Rattus norvegicus

World Journal of Biochemistry and Molecular Biology
Vol.2 , No. 6, Publication Date: Nov. 2, 2017, Page: 34-38

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Authors

[1]	Omale Jamila Audu, Biochemistry Department, Kogi State University, Anyigba, Nigeria.
[2]	Olajide Joseph Eniola, Biochemistry Department, Kogi State University, Anyigba, Nigeria.
[3]	Omale Aminu, Chemistry Department, Kogi State University, Anyigba, Nigeria.

Abstract

Reducing power antioxidant assay was carried out on garlic oil extract and ascorbic acid as standard. Effect of time and dose of garlic oil extract on Rattus novergicus was also studied. Obtained results revealed that there was an increase in reducing power values with increase in concentration of sample and standard (ascorbic acid) used. The sample extract (R² = 0.9993 for garlic oil) appears to have more reducing powers than the standard (R² = 0.978 for ascorbic acid). The lipid profile showed there was 4% reduction in total cholesterol from day 0 to day 7, an 8% reduction from day 7 to day 14 and 9% reduction from 14 to 21. There was a significant decrease in LDL-cholesterol by 42% from day 0 to 7; 7% decrease from day 7 to 14 and 29% decrease from day 14 to 21 and a decrease in triglyceride levels was also observed from day 0 to 7 by 3%, 51% from day 7 to 14 and 3% from day 14 to 21. Favourable and significant increase in HDL-cholesterol levels was noticed from days 0 to 7, 7 to 14 and 14 to 21 by 20%, 13% and 9% respectively. Garlic oil had a beneficial effect on the health of rats studied.

Keywords

Reducing Power, Garlic, Rattus novergicus, Cholesterol

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