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Vol.2 , No. 4, Publication Date: Sep. 14, 2017, Page: 16-19
. Treatment was carried out orally using aqueous and ethanol extracts of <i>Senna occidentalis</i> leaves at 200 mg/kg body weight once daily for 21-days. Serum bilirubin, platelets (PLT) and white blood count (WBC), lymphocytes (LYM) and red blood count (RBC) were evaluated. Diabetic condition caused significant increase (p<0.05) in WBC and PLT. Treatment of diabetic rats with aqueous extract and glibenclamide had no significant difference (p<0.05) from the diabetic control group, except the group treated with ethanol extract for WBC, but PLT was significantly lower (p<0.05) in aqueous extract and glibenclamide. Unlike WBC, LYM and RBC levels were significantly lower (p<0.05) in diabetic control. Hence treatment with extracts as well as glibenclamide caused significant increase in diabetic control in LYM and RBC levels. Serum bilirubin, PCV and Hb levels were significantly lower (p<0.05) in diabetic control compared to the normal control. Hence treatment with extracts caused significant increase bilirubin, PCV and Hb levels. The result of study showed to a large extent the effects of <i>Senna occidentalis</i> in the management of some complications resulting from diabetes and its complications.&picture=http://www.aascit.org/aascit/decorators/img/journal/832.jpg)
| [1] | Yakubu Ojochenemi Ejeh, Department of Biochemistry, Faculty of Pure and Applied Sciences, Federal University Wukari, Wukari, Nigeria. |
| [2] | Nwodo Okwesili Fred Chiletugo, Department of Biochemistry, Faculty of Biologocal Sciences, University of Nigeria, Nsukka, Nigeria. |
The present study was designed to evaluate the effects of Senna occidentalis in alloxan-induced diabetic and its complications in Wistar rats. Thirty male Wistar rats with body weight ranging from 180–250 g were selected for the study. Diabetes was induced by single intraperitoneal dose of alloxan injection (150 mg/ kg body weight). Treatment was carried out orally using aqueous and ethanol extracts of Senna occidentalis leaves at 200 mg/kg body weight once daily for 21-days. Serum bilirubin, platelets (PLT) and white blood count (WBC), lymphocytes (LYM) and red blood count (RBC) were evaluated. Diabetic condition caused significant increase (p<0.05) in WBC and PLT. Treatment of diabetic rats with aqueous extract and glibenclamide had no significant difference (p<0.05) from the diabetic control group, except the group treated with ethanol extract for WBC, but PLT was significantly lower (p<0.05) in aqueous extract and glibenclamide. Unlike WBC, LYM and RBC levels were significantly lower (p<0.05) in diabetic control. Hence treatment with extracts as well as glibenclamide caused significant increase in diabetic control in LYM and RBC levels. Serum bilirubin, PCV and Hb levels were significantly lower (p<0.05) in diabetic control compared to the normal control. Hence treatment with extracts caused significant increase bilirubin, PCV and Hb levels. The result of study showed to a large extent the effects of Senna occidentalis in the management of some complications resulting from diabetes and its complications.
Keywords
Senna occidentalis, Biochemical Complications, Diabetes
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