The interaction of copper chloride salt with Ceftazidime antibiotic has been studied using cyclic voltammetric technique in the potential range (+1.5 to -1.0) V at a scan rate 50 (mV/s) with mixed (MeOH+H2O) using NaClO4 (0.3M) as supporting medium and platinum as a working electrode at 298.15K. The voltammetry pattern of the blank medium didn't show any significant peak during the anodic and cathodic scans in the selected potential range while the peaks of the free metal ions clearly indicates a stripping anodic peak at ≈ 0.1V vs SCE (0.342 V vs NHE). This peak is due to the dissolution of metallic copper deposited during the cathodic scan between -0.1 to -0.5 V. The results of interactions of CuCl2.2H2O with CFZ in the ratio (1:1) and (1:2) are displayed and show regular decrease of the anodic peaks as a result of complexation of Cu ions with CFZ. In conclusion, both CFZ and alcohol had affected Cu ions deposition. The redox mechanism was explained also. The aim of the work is to estimate the stability constant and free energy of interaction between copper and the drug.
[1]
Z. Guo, Sadler, P. J. Angew. Chem. Int. Ed. 1999, 38, 1512-1531.
[2]
A. Sayah; English J. C. J. Am. Acad. Dermatol. 2005, 53, 2, 191-209.
[3]
S. Defazio, R. Cini; J. Chem. Soc., Dalton Trans. 2002, 1888-1897.
[4]
N. D. Baskaran, G. G. Gan, K. A. deeba and I. C. Sam, (2007), Int. J. In-fect. Dis., 23, 115-121
[5]
J. A. Claridge, N. M. Edwards, J. Swanson, T. C. Fabian, J. A. Weinberg, C. Wood and M. A. Croce, (2007); Surg. Infect. (Larchmt), 8, 83-90.
[6]
K. J. Eagye, J. L. Kuti and D. P. Nicolau, (2007); Surg. Infect. (Larchmt), 8, 215-226.
[7]
M. G. Martin, (2007), Leuk. Lymphoma", 48, 413-414.
[8]
V. Rodenas, M. S. Garcia, C. Sanchez-Pedreno, M. I. Albero, (1997), J. Pharm. Biomed. Anal., 15, 1687-1693.
[9]
G. Adamis, M. G. Papaioannou, P. Giamarellos-Bourboulis, E. J. Gargalianos, J. Kosmidis, H. Giamarellou, (2004), Int. J. Anti-microb. Agents, 23, 144-149.
[10]
A. R. Gennaro and Remington; "The Science and Practice of Pharmacy"; 20th ed., Rio de Janeiro, Brazil: Guanabara Koogan, (2004).
[11]
Martindale, "The Complete Drug Reference", London, England: Pharmaceutical Press, (2005).
[12]
M. Arséne, P. Favetta, B. Favier, and J. Bureau, (2002), J. Clin. Pharm. Therap., 27, 205-209.
[13]
J. G. Hardman and L. E. Limbird, The Pharmacological Basis of Therapeutics, New York, NY: McGraw-Hill Book Co., (2006).
[14]
J. M. Bobbitt and Wills, P. John; J. Org. Chem., 45, 1978 (1980).
[15]
F. S. Nelsen., Kessel, R. Carl, Brien, J. David and W. Frank; J. Org. Chem., 45, 2116 (1980).
[16]
Powers, J. Michael and Meyer and J. Thomas; J. Amer. Chem. Soc, 102, 1289 (1978).
[17]
Taric Derya, Dogan-Topal Burcu, Golcu Aysegul, Ozkan A. Sibel, Current analytical Chemistry, 2014, 69 (9), 981-990.
[18]
N. A. El-Maali, A. H. Osman, A. A. Aly, G. A. A. Bioelectrochem., 2006, vol. 2, p. 95.
[19]
Aftab Ali Shaikh, Badrunnessa, Jannatual Firdaws, M D Shahidur Rahman, Nishat Ahmed Pasha and Prdip Kumar Bakshi, Journal of Bagladesh Chemical Society, 2011, 24 (2), 158-164.
[20]
K. Kalyanasundaram, J. Kiwi, M. Gratze1; Helv. Chem. Acta. 61. 2720 (1978).
[21]
A. C. Rice and T. J. Spence; Inorg. Chem, 19, 2845 (1980).
[22]
B. J. Headridge, "Electrochemical Techniques for lnorganic Chemists," Academic Press, London and New York (1969).
[23]
Esam A. Gomaa, Physics and Chemistry of Liquids, 50 (2012) 279 -283, Elsayed M. Abouelleef, Esam A. Gomaa, Shereen E. Salem, American Journal of Chemistry and Application, 2 (1), 2015, 1-11.
[24]
Esam A. Gomaa, International Journal of Materials and Chemistry, 2 (1), (2012) 16–18.
[25]
Esam A. Gomaa, American Journal of Environmental Engineering 2 (3), (2012) 54-57.
[26]
Esam A. Gomaa, American Journal of Polymer Science 2 (3), (2012) 35–47.
[27]
Esam A. Gomaa, Eur. Chem. Bull, 1 (2013) 259-261.
[28]
Esam A. Gomaa, Elsayed M. Abou Elleef and E. A. Mahmoud, Eur, Chem. Bull, 2 (2013), 732-735.
[29]
Esam A. Gomaa, Elsayed M. Abou Elleef, American Chemical Science Journal, 3 (2013), 489-499.
[30]
Esam A. Gomaa, Elsayed M. Abou Elleef, Science and Technology, 3 (2013) 118-122.
[31]
Esam A. Gomaa, International Journal of Theoretical and Mathematical Physics, 3 (2012) 151-154.
[32]
Esam A. Gomaa, and B. A. Al- Jahdali, Education, 2 (3), (2012), 25-28.
[33]
Esam A Gomaa, Orient. J. Chem., 6 (1990) 12-16 and E. A. Gomaa, Indian J. of Tech, 24 (1986) 725.
[34]
E. A. Gomaa and G. Begheit, Asian J. of Chem., 2 (1990) 444 and E. A. Gomaa, A. H. El-Askalany and M. N. H. Moussa. Asian J. Chem, 4 (1992) 553.
[35]
Esam A. Gomaa, and, Elsayed M. Abou-Elleef, Thermal and Power Engineering, 3 (2014) 47-55.
[36]
Esam A. Gomaa, Research and Reviews: Journal of Chemistry 3 (2014) 28-37.
[37]
Esam A. Gomaa, A. H. El-Askalany and M, N, H, Moussa, Rev Roum. Chim, 3 (1987) 243
[38]
Esam A Gomaa, Theromochimica Acta, 128 (1988) 99.
[39]
Esam A Gomaa, Indian J. of Tech., 24 (1986) 725 and E. A. Gomaa. Thermochim. Acta, 80 (1984) 355.
[40]
Esam A Gomaa, Croatica Chimica Acta, 62 (1989) 475.
[41]
E. A. Gomaa, A. M. Shallapy and M. N. H. Moussa. Asian J. of Chem., 4, 518 (1992).
[42]
M. A. Mousa, E. A. Gomaa, A. A. El-Khouly, A. A. M. Aly, H. F. Aly. J. Rational. Nucl. Chem. Lett., 87 (1984) 81.
[43]
Esam A Gomaa, M. A. Mousa and A. A. El-Khouly, Thermochimica Acta, 86 (1985) 351.
[44]
Esam A Gomaa, M. A. Mousa and A. A. El-Khouly, Thermochimica Acta, 89 (1985) 133, E. A. Gomaa and B. A. M. Al Jahdali, Science and Technology, vol. 2, No. 4, (2012) 1-8.
[45]
Esam A Gomaa, Thermochimica Acta, 91 (1985) 235 and A. B. Kashyout, H. M. A. Soliman, Marwa Fathy, E. A Gomaa and Ali Zidan, International Journal of photoenergy, 2012, 1-7.
[46]
Esam A Gomaa, Theromchimica Acta, 128 (1988) 287 and Esam A. Gomaa, Frontiers in Science, 2 (2012) 24-27.
[47]
Esam A Gomaa, Thermochimica Acta, 140 (1989) 7 and E. A. Gomaa, K. M. Ibrahim and N. M. Hassan, The international Journal of Engineering and Science (IJES), 3 (2014) 44-51.
[48]
Esam A Gomaa, Bull, Soc. Chim, Fr., 5 (1989) 620 and E. A. Gomaa, H. M. Abu El-Nader, Sh. E. Rashed, Physical Chemistry, 2012, 2 (3); 9-17.
[49]
Esam A Gomaa, Bull. Soc. Chim Fr., 5 (1989) 371.
[50]
Esam A Gomaa, Thermochimica Acta, 152 (1989) 371.
[51]
Esam A Gomaa, Thermochimica Acta, 156 (1989) 91.
