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AASCIT Communications | Volume 3, Issue 3 | May 13, 2016 online | Page:160-168
Complexation of Ceftazidime Antibiotic with Copper Chloride Salt in Mixed (MeOH+H2O) Solvents
Abstract
The complexation reaction between Ceftazidime antibiotic (CFZ) and copper chloride salt (CuCl2.2H2O) was studied in mixed (MeOH+H2O) using conductometric measurements. The association parameters of CuCl2.2H2O salt in mixed (MeOH+H2O) with the presence of CFZ were easily calculated using Fuoss-Shedlovsky equation at different temperatures 293.15, 298.15, 303.15 and 308.15K. It was observed that, the limiting molar conductances decrease by increasing temperature due to more association. Also, the thermodynamic parameters of complexation between CuCl2.2H2O salt and CFZ were calculated to found the formation of (1:2) and (1:1) M/L complexes. The (1:1) M/L complex has greater formation thermodynamic values for CuCl2.2H2O by its interaction with CFZ at all the temperatures used.
Authors
[1]
E. A. Gomaa, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
[2]
S. E. Salem, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Keywords
Ceftazidime Antibiotic (CFZ), Copper Chloride Salt (CuCl2.2H2O), Fuoss-Shedlovsky Method, Gibbs Free Energy Change (ΔG), Enthalpy Change (ΔH) and Entropy Change (ΔS)
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Arcticle History
Submitted: Mar. 6, 2016
Accepted: Apr. 5, 2016
Published: May 13, 2016
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