It is well known for using acetylsalicylic acid (ASA) as tablets of aspirin, one of medicines for chronic diseases and for the benefit of the desired of this medicine and in particular the older ages in life to prevent blood clotting and for stroke. The aim of the study was to finding the affected of aspirin as chemical composition in blood medium using cyclic voltammetric method by glassy carbon electrode. It was found that the oxidative current peaks of ASA in both normal saline and blood medium appeared in voltammograms, also many reduction current peaks in normal saline and blood medium was found. The oxidation current peak of ASA in blood and normal saline medium was reduced in present with each of AA and FA, also enhanced the reduction current peaks by these reagents (AA and FA). The chemical composition of both AA and FA acts as antioxidant reagent in blood medium in present with ASA, so patient can be taken aspirin in safety using with these reagents.
[1]
Muhammed Mizher Radhi, Wee Tee Tan, Mohamad Zaki B. Ab Rahman and Anuar Bin Kassim, Voltammetric Detection of Mn (II) in Blood Sample at C60 and MWCNT Modified Glassy Carbon Electrodes. American Journal of Applied Sciences 7 (3): 439-445, 2010.
[2]
Muhammed M. Radhi, Dawood S. Dawood, Nawfal K. Al-Damlooji and Tan W. Tee, Development of Electrochemical Sensors for the Detectionof Mercury by CNT/Li+, C60/Li+ and Activated Carbon Modified Glassy Carbon Electrode in Blood Medium Sensors & Transducers Journal, Vol. 146, Issue 11, November 2012, pp. 191-202.
[3]
Muhammed Mizher Radhi, Nawfal Khalid Al-Damlooji, Baquir Kareem Abed, Dawood Salman Dawood, and Tan Wee Tee, Electrochemical Sensors for Detecting Mn (II (in Blood Medium Sensors & Transducers, Vol. 149, Issue 2, February 2013, pp. 89-93.
[4]
Muhammed Mizher Radhi, Nawfal K. Al-Damlooj, Mahmood Radhi Jobayr, Dawood S. Dawood, Electrochemical Sensors of Cyclic Voltammetry to Detect Cd (II) in Blood Medium Sensors & Transducers, Vol. 155, Issue 8, August 2013, pp. 150-154. 1. Muhammed.
[5]
Muhammed Mizher Radhi, Hanaa Naji Abdullah, Sura A. Al-Asadi, Emad A. Jaffar Al-Mulla, Electrochemical oxidation effect of ascorbic acid on mercury ions in blood sample using cyclic voltammetry, Int J Ind Chem, 6 (4), 311-316, 2015.
[6]
Eder Tadeu Gomes Cavalheiro & Christopher M. A. Brett & Ana Maria Oliveira-Brett & Orlando Fatibello-Filho, Bioelectroanalysis of pharmaceutical compounds, Bioanal Rev (2012) 4: 31 53.
[7]
Veronika Supalkova, Jiri Petrek, Ladislav Havel, Sona Krizkova, Jitka Petrlova, Vojtech Adam, David Potesil, Petr Babula, Miroslava Beklova, Ales Horna and Rene Kizek, Electrochemical Sensors for Detection of Acetylsalicylic Acid, Sensors 2006, 6, 1483-1497.
[8]
Denley Evans, John P. Hart and Glan Rees, Voltammetric behaviour of salicylic acid at a glassy carbon electrode and its determination in serum using liquid chromatography with amperometric detection, Analyst, 1991, 116, 803-806.
[9]
Jesus F. Arteaga, Mercedes Ruiz-Montoya, Alberto Palma, Gema Alonso-Garrido, Sara Pintado and Jose M. Rodriguez-Mell, Comparison of the Simple Cyclic Voltammetry (CV) and DPPH Assays for the Determination of Antioxidant Capacity of Active Principles, Molecules 2012, 17, 5126-5138.
[10]
Zhihua Wang, Hui Li, Jing Chen, Zhonghua Xue, Bowan Wu, Xiaoquan Lu., Acetylsalicylic acid electrochemical sensor based on PATP-AuNPs modified molecularly imprinted polymer film. Talanta. 2011 Sep 15; 85 (3): 1672-1679.
[11]
Codrut¸ Cofan and Ciprian Radovan, Anodic Determination of Acetylsalicylic Acid at a Mildly Oxidized Boron-Doped Diamond Electrode in Sodium Sulphate Medium, International Journal of Electrochemistry, Volume 2011, Article ID 451830, 9 pages, doi: 10.4061/2011/451830
[12]
Laercio Rover Junior, Graciliano de Oliveira Neto, Joao Roberto Fernandes, Lauro Tatsuo Kubota, Determination of salicylate in blood serum using an amperometric biosensor based on salicylate hydroxylase immobilized in a polypyrrole–glutaraldehyde matrix, Talanta 51 (2000) 547–557.
[13]
Angel A. J. Torriero a, Juan M. Lucoa, Leonides Sereno b, Julio Rabaa, Voltammetric determination of salicylic acid in pharmaceuticals formulations of acetylsalicylic acid, Talanta 62 (2004) 247–254.
[14]
Hanaa S. El-Desoky; Mohamed M. Ghoneim; Allia. D. Habazy, Voltammetry of irbesartan drug in pharmaceutical formulations and human blood: quantification and pharmacokinetic studies, J. Braz. Chem. Soc. vol. 22 no. 2 São Paulo Feb. 2011.
[15]
Edyta Wudarska, Ewa Chrzescijanska and Elzbieta Kusmierek, Electroreduction of Salicylic Acid, Acetylsalicylic Acid and Pharmaceutical Products Containing these Compounds, Port. Electrochim. Acta, vol. 32 (4) 2014.
[16]
Zekerya Dursun, Levent PEL˙ IT, Isao Taniguchi, Voltammetric Determination of Ascorbic Acid and Dopamine Simultaneously at a Single Crystal Au (111) Electrode, Turk J Chem 33 (2009), 223–231.
[17]
J. K. Goh, W. T. Tan, F. T. Lim and N. A. M. Maamor, electrochemical oxidation of ascorbic acid mediated by carbon nanotubes /Li+ / carbon paste modified solid electrode, The Malaysian Journal of Analytical Sciences, Vol 12, No 2 (2008): 480–485.
[18]
González MJ, Mora E, Riordan NH, Riordan HD, Mojica P. Rethinking vitamin C and cancer: an update on nutritional oncology. Cancer Prev Intl. 1998; 3: 215–24.
[19]
Terwecoren A, Steen E, Benoit D, Boon P, Hemelsoet D, Ischemic stroke and hyperhomocysteinemia. Acta Neurol Belg 109 (3): 181–8 (2009).
