Plasma dialysis, which involves separation of blood cells from the plasma before the dialyzer, allowing only for the passage of plasma through the dialyzer canal. The aim of this study was to suggest novel model of high efficacy plasma dialysis as hemodialysis alternative. Electron microscopy imaging of the capillary lumens following an investigation plasma dialysis and hemodialysis were performed. Full blood clearance index was calculated, basing on the percent reduction of creatinine level before and after the dialysis both for the typical hemodialysis and plasma dialysis. Visualization of the plasma dialysis procedure indication decrease in the number of attached blood cells of compared to the hemodialysis. Creatinine clearance index ranged 79-86% for the hemodialysis and decreased over time during the procedure, while for plasma dialysis ranged from 94 to 95%. Also, no decreasing trend in procedure efficacy over time was found. Based on the experimental data two models for dialyzers were designed: rotary dialyzer and dialyzer with double capillary walls. Plasma dialysis may allow for the improved plasma clearance with estimated about 20% higher efficacy compared to the hemodialysis based systems, be useful in the setting of relatively low blood flow (for example 100- 150 ml/min) and may reduce duration and frequency of dialysis procedures.
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