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AASCIT Communications | Volume 2, Issue 4 | May 13, 2015 online | Page:109-114
In Vivo Investigation of the Interaction of Ampicillin (AMP), Oxytetracycline (OTC) and 2-Mercaptoimidazol (MI) with Calcium Chloride Salt
The interaction of antibiotic Interaction of Ampicillin, Oxytetracycline and 2-Mercaptoimidazol with some Salts has been investigated by In vivo studies. It’s found that there were no significant changes observed in the mean value of serum ionized calcium of the treated rats compared with the corresponding levels of control untreated rat group upon treatment with 1.4 mg/kg body weight. This is an interesting result because calcium complex ion in aqueous solutions with AMP, MI and OTC, but the same investigated compounds doesn’t show significant decrease in serum ionized calcium and Sodium due to the ability of the compounds to form complexes with calcium and Sodium at physiological conditions i.e. (inside living organisms).So administration of those compounds has no side effect on serum ionized calcium on developing any hypocalcaemia related diseases.
Esam A. Gomaa, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Amr Negm, Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
Elsayed T. Helmy, Chemistry Department, Mansoura College Higher Institute for Engineering and Technology, Talkha, Manoura, Egypt.
In Vivo, Stability Constant, Ampicillin, Oxytetracycline and 2-Mercaptoimidazol
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Arcticle History
Submitted: Apr. 24, 2015
Accepted: May 4, 2015
Published: May 13, 2015
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