ISSN: 2375-3838
International Journal of Clinical Medicine Research  
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Comparative Haematological Evaluation of Sickle Cell Anaemic Patients in Steady State and During Vaso-occlusive Crisis at Maiduguri, Nigeria
International Journal of Clinical Medicine Research
Vol.4 , No. 5, Publication Date: Aug. 29, 2017, Page: 51-55
944 Views Since August 29, 2017, 768 Downloads Since Aug. 29, 2017
 
 
Authors
 
[1]    

Usman A Abjah, Department of Haematology, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.

[2]    

Jessy T Medugu, Department of Medical Laboratory Science, College of Medical Sciences, University of Maiduguri, Nigeria.

[3]    

Haruna Ayuba Bulama, Department of Medical Laboratory Science, College of Medical Sciences, University of Maiduguri, Nigeria.

[4]    

Idris Abdullahi Nasir, Department of Medical Laboratory Services, University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria.

[5]    

John Kankop Wakbe, Department of Haematology, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.

[6]    

Ghapouen Amed Bachir Peyou, Department of Medical Laboratory Science, College of Medical Sciences, University of Maiduguri, Nigeria.

 
Abstract
 

Background: Sickle cell disease (SCD) is a hereditary haemoglobinopathy characterized by deranged haematopoiesis, and intermittent occlusion of small blood vessels. Patients can be in relative good health “steady state” which may be punctuated by acute exacerbations called “crisis” believed to be precipitated by factors that may affect their haematological indices. Methods: This prospective study involved 100 subjects consecutively recruited from haematology day care clinics of the University of Maiduguri Teaching Hospital. This comprised 50 sickle cell anaemia patients (HbS HbS) in vaso-occlusive crisis and 50 sickle cell anaemia patients (HbS HbS) in steady state. EDTA anticoagulated blood samples were collected from all subjects for the determination of packed cell volume, white blood cell counts, platelet counts and differential leukocyte counts using standard methods. Results: The mean age ± standard deviations of the subjects in steady state and in vaso-occlusive crisis are 23.94±7.14 and 23.60±6.28. The packed cell volume of patients in steady state and those in crisis are 0.18±0.05 and 0.17±0.04, respectively (p =0.58); the white blood counts of patients in steady state and those in crisis are 14.21±4.27 and 14.56±4.77, respectively (p-value 0.70) and the platelet counts of patients in steady state and those in crisis are 121.44±3.61 and 110.14±3.81, respectively with (p =0.21). The differential leukocyte counts of patients in steady state versus those in crisis are neutrophils. There is no significant statistical difference (p˃0.05) in the mean values of PCV, WBC count, Platelet count and differential white cell count between sickle cell patients in steady state and during vaso-occlusive crisis. Conclusion: Findings from this study showed that there is no difference in the haematological parameters of sickle cell anaemic patients in crisis state from those in stable state. However, detailed red cell indices could provide baseline data that would be used in effective evidenced-based management of sickle cell diseases.


Keywords
 

Sickle Cell, Vaso-occlusive Crisis, Steady State, Haemoglobinopathy


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